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TGFβ RII (E246) polyclonal antibody

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Nanjing bioworld biotech CO.,Ltd

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Scintila, s.r.o.
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Divbio Science Europe
P.O. Box 92
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BioTag Ltd.
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Valter Occhiena S.r.l.
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GenomicsOne co., Ltd
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Divbio Science Europe
P.O. Box 92
4850 AB Ulvenhout The Netherlands
phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

Divbio Science Europe
P.O. Box 92
4850 AB Ulvenhout The Netherlands
phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

Divbio Science Europe
P.O. Box 92
4850 AB Ulvenhout The Netherlands
phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

 

Sanbio B.V. Frontstraat 2c,5405 PB Uden,The Netherlands 
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FAX: +31(0)413 266 605
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BIOLUTION RESOURCES (002247091-D)
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Bita Lifescience Sdn Bhd.

C-23-05, Dataran 32,No. 2, Jalan 19/1,46300 Petaling Jaya,Selangor Darul Ehsan,Malaysia
Tel: 603-7960-8286
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i-DNA Genetics Pte. Ltd.
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Divbio Science Europe
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The Netherlands
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fax: +31 (0)76 201 1229
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Sanbio B.V. Frontstraat 2c,5405 PB Uden,The Netherlands 

Tel.: +31(0)413 251 115 
FAX: +31(0)413 266 605
Email : sanbio@sanbio.nl 
Website: sanbio.nl 

Nordic BioSite AS
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Tel: 800 10 301
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Divbio Science Europe
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phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

BIOLIM
81-526 Gdynia,Swierkowa 30/6,Poland
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Fax: 48 58 746 38 03
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Genomax Technologies Pte Ltd.
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Afirmus Biosource Pte Ltd
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AntibodyBcn (ABBCN, SL ) 
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Abyntek Biopharma,S.L.
Parque Tecnológico de Bizkaia, Edificio 504, 48160 Derio - Bizkaia (Spain)
Tel.: (+34) 94 404 8080
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Biologist Group d.o.o.
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Website: www.biologist.rs 

Email: g.mitrovic@biologist.rs

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Propellervägen 4A,S-183 62 Täby,Sweden
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Divbio Science Europe
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ASIA BIOSCIENCE CO.,LTD.

Contact: Mr. Jimmy Chen

Address: 1 F, No.1, Lane 661, Wenlin Road, Shihlin District, Taipei City 111, Taiwan

Phone: +886-2-8866-3366

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Catalog No.BS1696
Product NameTGFβ RII (E246) polyclonal antibody
ApplicationsWB IHC
Alternative NameTGF-beta receptor type-2; TGFR-2; TGFR2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2
Swiss-ProtP37173
HostRabbit
ReactivityHuman,Mouse,Rat
Application_allWB: 1:500~1:1000 IHC: 1:50~1:200
Product1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Purification&PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&StabilityStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SpecificityTGFβ RII (E246) polyclonal antibody detects endogenous levels of TGFβ RII protein.
BiowMW~ 65 kDa
NoteFor research use only, not for use in diagnostic procedure.
ImmunogenSynthetic peptide, corresponding to amino acids 220-300 of Human TGFβ RII.
  • Western blot (WB) analysis of TGFβ RII (E240) polyclonal antibody at 1:500 dilution
    Lane1:A549 whole cell lysate
    Lane2:NIH-3T3 whole cell lysate
    Lane3:H9C2 whole cell lysate
  • Immunohistochemistry (IHC) analyzes of TGFβ RII (E246) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.
  • Western blot (WB) analysis of TGFβ RII (E246) pAb at 1:500 dilution
    Lane1:A549 whole cell lysate(40ug)
    Lane2:PC12 whole cell lysate(40ug)

Background

A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor (TGFβ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFβ-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFβ type I receptor proteins designated ALK-5 (TβR-1) and TSR-1, respectively.

References for TGFβ RII (E246) polyclonal antibody

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For Research Use Only. Not For Use In Diagnostic Procedures.

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