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p-MSK1(Thr581) Peptide

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P.O. Box 92
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phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
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twitter #divbiobiotech 

Divbio Science Europe
P.O. Box 92
4850 AB Ulvenhout The Netherlands
phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

Divbio Science Europe
P.O. Box 92
4850 AB Ulvenhout The Netherlands
phone  +31 (0)76 565 1680
fax  +31 (0)76 201 1229
website   www.divbio.nl 
email       info@divbio.nl 
twitter #divbiobiotech 

 

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Evolve Life Sciences Pty Ltd 
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Nordic BioSite AS
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P.O. Box 92
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fax  +31 (0)76 201 1229
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Catalog No.AP0095P
Product Namep-MSK1(Thr581) Peptide
ApplicationsBlocking
Alternative NameRibosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL; RPS6KA5; MSK1
Swiss-ProtO75582
Product1 mg/ml in DI water.
Purification&PuritySynthetic peptide p-MSK1(Thr581). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage&StabilityStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SpecificityThis peptide can be used with studies using AP0095 p-MSK1(Thr581) pAb.

Background

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.

References for p-MSK1(Thr581) Peptide

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