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F4/80 Rat monoclonal antibody RB0001
Product NameF4/80 Rat monoclonal antibody
Catalog No.RB0001
Swiss-ProtQ14246
Host Rat
ReactivityHuman, Mouse
ApplicationsWB IF IHC(P)
Application_allWB:1:100-1:1,000 IF:1:50-500 IHC:1:50-500 FC:1μgper1x106cells
BiowMW160 kDa
Alternative NameADGRE1, ADGRE1, Adhesion G protein coupled receptor E1, Adhesion G protein-coupled receptor E1, AGRE1, Cell surface glycoprotein EMR1, Cell surface glycoprotein F4/80, DD7A5 7, Egf like module containing mucin like hormone receptor like 1, Egf like module containing mucin like hormone receptor like sequence 1, EGF like module receptor 1, EGF TM7, EGF-like module receptor 1, EGF-like module-containing mucin-like hormone receptor-like 1, EGFTM7, EMR 1, EMR1 hormone receptor, Gpf480, Ly71, Lymphocyte antigen 71, TM7LN3,
Purification&PurityImmunogen affinity purified
ConjugateUnconjugated
ModificationUnmodification
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Size Price
50ul $258
100ul $398
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Product Name :
F4/80 Rat monoclonal antibody
Background :
The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL. These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system. The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13. The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin. F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation. The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.
Product :
Rat IgG in 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage&Stability :
Store at +4°C
Specificity :
F4/80 Rat monoclonal antibody detects endogenous levels of F4/80 protein.
Immunogen :
peptide
Conjugate :
Unconjugated
Modification :
Unmodification
Price/Size :

$368/1mg.
Tips: For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).

Function :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

Format and storage :

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Precautions :

This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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