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β-Actin (I102) polyclonal antibody AP0060
  • Western blot (WB) analysis of β-Actin (I102) pAb at 1:5000/1:10000/1:20000 dilution Lane1:CT-26 whole cell lysate(40ug) Lane2
Product Nameβ-Actin (I102) polyclonal antibody
Catalog No.AP0060
Swiss-ProtN/A
Host Rabbit
ReactivityHuman,Mouse,Rat
ApplicationsWB
Application_allWB:1:5000~1:20000
BiowMW~ 42 kDa
Alternative NameActin, cytoplasmic 1; Beta-actin; Actin, cytoplasmic 1, N-terminally processed; ACTB; Actin-β; Beta actin;
Purification&PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ConjugateUnconjugated
ModificationUnmodification
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50ul $148
100ul $258
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Product Name :
β-Actin (I102) polyclonal antibody
Background :
All eukaryotic cells express actin, which often constitutes asmuch as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of actin are present in mammalian tissues and fall into three classes. -actin expression is limited to various types of muscle, whereas – and -actin are the principle constituents of filaments in other tissues.Members of the small GTPase family regulate the organization of the actin cytoskeleton. Rho controls the assembly of ctin stress fibers and focal adhesion, Rac regulates ctin filament accumulation at the plasma membrane and Cdc42 stimulates formation of filopodia.
Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :
β-actin (I102) polyclonal antibody detects endogenous levels of β-actin protein.
Immunogen :
Recombinant full length Human β-Actin.
Conjugate :
Unconjugated
Modification :
Unmodification
  • Western blot (WB) analysis of β-Actin (I102) pAb at 1:5000/1:10000/1:20000 dilution Lane1:CT-26 whole cell lysate(40ug) Lane2
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PMCID:    Pubmed No.:26527034 3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice. PMCID:    Pubmed No.:24053646 Involvement of Pregnane X Receptor in the Impaired Glucose Utilization Induced by Atorvastatin in Hepatocytes PMCID:    Pubmed No.:26616219 TSG attenuates LPC‐induced endothelial cells inflammatory damage through notch signaling inhibition PMCID:    Pubmed No.:26662286 Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries PMCID:    Pubmed No.:26758245 Lipoxin A 4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells PMCID:    Pubmed No.:26845617 Proteasome Inhibition-Induced Downregulation of Akt/GSK-3β Pathway Contributes to Abnormality of Tau in Hippocampal Slice PMCID:    Pubmed No.:24752588 Maternal protein restriction during gestation and lactation programs offspring ovarian steroidogenesis and folliculogenesis in the prepubertal gilts PMCID:    Pubmed No.:24787658 Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells PMCID:    Pubmed No.:24779927 Melatonin stimulated antioxidant enzymes and reduced oxidative stress in experimental traumatic brain injury: The Nrf2-ARE signaling pathway as a potential mechanism. 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PMCID:    Pubmed No.:24686082 Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway. PMCID:    Pubmed No.:24690200 Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium decorticatum PMCID:    Pubmed No.:24694116 mTOR-targeted therapy: differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response PMCID:    Pubmed No.:24704448 The mechanisms of 5-FU-PLA-O-CMC-NPS-mediated inhibition of the proliferation of colorectal cancer cell line SW480 PMCID:    Pubmed No.:24740560
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

Price/Size :

USD 368/1mg/vial



Tips: 

For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).

Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 


Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.
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