Product Name :
β-Actin (I102) polyclonal antibody Background :
All eukaryotic cells express actin, which often constitutes asmuch as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of actin are present in mammalian tissues and fall into three classes. -actin expression is limited to various types of muscle, whereas – and -actin are the principle constituents of filaments in other tissues.Members of the small GTPase family regulate the organization of the actin cytoskeleton. Rho controls the assembly of ctin stress fibers and focal adhesion, Rac regulates ctin filament accumulation at the plasma membrane and Cdc42 stimulates formation of filopodia. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
β-actin (I102) polyclonal antibody detects endogenous levels of β-actin protein. Immunogen :
Recombinant full length Human β-Actin. Conjugate :
Unconjugated Modification :
Unmodified
β-Actin (I102) polyclonal antibody Background :
All eukaryotic cells express actin, which often constitutes asmuch as 50% of total cellular protein. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. While lower eukaryotes, such as yeast, have only one actin gene, higher eukaryotes have several isoforms encoded by a family of genes. At least six types of actin are present in mammalian tissues and fall into three classes. -actin expression is limited to various types of muscle, whereas – and -actin are the principle constituents of filaments in other tissues.Members of the small GTPase family regulate the organization of the actin cytoskeleton. Rho controls the assembly of ctin stress fibers and focal adhesion, Rac regulates ctin filament accumulation at the plasma membrane and Cdc42 stimulates formation of filopodia. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
β-actin (I102) polyclonal antibody detects endogenous levels of β-actin protein. Immunogen :
Recombinant full length Human β-Actin. Conjugate :
Unconjugated Modification :
Unmodified
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Western blot (WB) analysis of β-Actin (I102) pAb at 1:5000/1:10000/1:20000 dilution Lane1:CT-26 whole cell lysate(40ug) Lane2
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Porcine Glucocorticoid Receptor (< i> NR3C1) Gene: Tissue-Specificity of Transcriptional strength and Glucocorticoid Responsiveness of Alternative Promoters
PMCID: Pubmed No.:24503296
Pre-treatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury
PMCID: Pubmed No.:24387843
Cigarette smoke-induced alveolar epithelial-mesenchymal transition is mediated by Rac1 activation
PMCID: Pubmed No.:24508121
c-Abl Tyrosine Kinase Mediates Neurotoxic Prion Peptide-Induced Neuronal Apoptosis via Regulating Mitochondrial Homeostasis
PMCID: Pubmed No.:24510275
Sox9 Potentiates BMP2-Induced Chondrogenic Differentiation and Inhibits BMP2-Induced Osteogenic Differentiation
PMCID: Pubmed No.:24551211
Activation of intrinsic apoptotic signaling pathway in cancer cells by< i> Cymbopogon citratus polysaccharide fractions
PMCID: Pubmed No.:24702929
Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release
PMCID: Pubmed No.:24562307
Activation of matrix metalloproteinase-26 by HOXA10 promotes embryo adhesion in vitro.
PMCID: Pubmed No.:24565841
Hemokinin-1 (4-11)-Induced Analgesia Selectively Up-Regulates δ-Opioid Receptor Expression in Mice
PMCID: Pubmed No.:24587368
Luteoloside Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Inhibition of NLRP3 Inflammasome
PMCID: Pubmed No.:24587153
Luteolin provides neuroprotection in the models of traumatic brain injury via Nrf2-ARE pathway
PMCID: Pubmed No.:24642087
Granulocyte/Macrophage Colony-Stimulating Factor Influences Angiogenesis by Regulating the Coordinated Expression of VEGF and the Ang/Tie System
PMCID: Pubmed No.:24658178
Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells.
PMCID: Pubmed No.:24666416
Phosphorylation of heat shock protein 27 antagonizes TNF-α induced HeLa cell apoptosis via regulating TAK1 ubiquitination and activation of p38 and ERK signaling.
PMCID: Pubmed No.:24686082
Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway.
PMCID: Pubmed No.:24690200
Induction of ROS-Dependent Mitochondria-Mediated Intrinsic Apoptosis in MDA-MB-231 Cells by Glycoprotein from Codium decorticatum
PMCID: Pubmed No.:24694116
mTOR-targeted therapy: differential perturbation to mitochondrial membrane potential and permeability transition pore plays a role in therapeutic response
PMCID: Pubmed No.:24704448
The mechanisms of 5-FU-PLA-O-CMC-NPS-mediated inhibition of the proliferation of colorectal cancer cell line SW480
PMCID: Pubmed No.:24740560
Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial–mesenchymal transition and renal fibrosis in diabetic nephropathy
PMCID: Pubmed No.:26151815
Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial–mesenchymal transition and renal fibrosis in diabetic nephropathy
PMCID: Pubmed No.:26151815
Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-κB Axis via AMPK Activation
PMCID: Pubmed No.:28512854
Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming
PMCID: Pubmed No.:27308893
Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment
PMCID: Pubmed No.:26527034
Angiotensin(1–7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit
PMCID: Pubmed No.:27445100
Lipoxin A4 attenuates LPS-induced mouse acute lung injury via Nrf2-mediated E-cadherin expression in airway epithelial cells
PMCID: Pubmed No.:26845617
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion
PMCID: Pubmed No.:27884164
Advanced Glycation Endproducts Impair Endothelial Progenitor Cell Migration and Homing via Syndecan 4 Shedding
PMCID: Pubmed No.:27662820
Resveratrol ameliorates hyperglycemia-induced renal tubular oxidative stress damage via modulating the SIRT1/FOXO3a pathway
PMCID: Pubmed No.:28258028
Cyclin-Dependent Kinase Inhibitor 3 Promotes Cancer Cell Proliferation and Tumorigenesis in Nasopharyngeal Carcinoma by Targeting p27
PMCID: Pubmed No.:28109073
Folate-targeted nanoparticle delivery of androgen receptor shRNA enhances the sensitivity of hormone-independent prostate cancer to radiotherapy
PMCID: Pubmed No.:28185938
Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters
PMCID: Pubmed No.:28083805
Mineral trioxide aggregate enhances the osteogenic capacity of periodontal ligament stem cells via NF‐κB and MAPK signaling pathways
PMCID: Pubmed No.:28749049
Dexamethasone Downregulates SLC7A5 Expression and Promotes Cell Cycle Arrest, Autophagy and Apoptosis in BeWo Cells
PMCID: Pubmed No.:26094588
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma
PMCID: Pubmed No.:29075359
S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
PMCID: Pubmed No.:27256110
d‐Chiro inositol ameliorates endothelial dysfunction via inhibition of oxidative stress and mitochondrial fission
PMCID: Pubmed No.:28087886
eEF2K promotes progression and radioresistance of esophageal squamous cell carcinoma
PMCID: Pubmed No.:28431753
Fms related tyrosine kinase 1 (Flt1) functions as an oncogene and regulates glioblastoma cell metastasis by regulating sonic hedgehog signaling
PMCID: Pubmed No.:28560064
Effect of HM910, a novel camptothecin derivative, on the inhibition of multiple myeloma cell growth in vitro and in vivo
PMCID: Pubmed No.:26045982
Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats
PMCID: Pubmed No.:27180978
The edaravone and 3- n -butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats
PMCID: Pubmed No.:26073328
Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice
PMCID: Pubmed No.:25732597
Combined Erlotinib and PF‐03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma
PMCID: Pubmed No.:29232766
Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice
PMCID: Pubmed No.:28235543
Toxic effects of 56Fe ion radiation on the zebrafish (Danio rerio) embryonic development
PMCID: Pubmed No.:28267650
LFG-500, a newly synthesized flavonoid, attenuates lipopolysaccharide-induced acute lung injury and inflammation in mice
PMCID: Pubmed No.:27206337
Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages
PMCID: Pubmed No.:27144994
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment
PMCID: Pubmed No.:26826245
YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKCδ/Drp1-Mediated Excessive Mitochondrial Fission
PMCID: Pubmed No.:29435096
MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A∗0201 alleles
PMCID: Pubmed No.:26058806
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency
PMCID: Pubmed No.:29117896
Enhancing the anti-multiple myeloma efficiency in a cancer stem cell xenograft model by conjugating the ABCG2 antibody with microbubbles for a targeted delivery of ultrasound mediated epirubicin
PMCID: Pubmed No.:28232025
Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
PMCID: Pubmed No.:27184504
3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome
PMCID: Pubmed No.:26588861
Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes
PMCID: Pubmed No.:26616219
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway
PMCID: Pubmed No.:28038913
Transforming growth factor‐β1 stimulates hedgehog signaling to promote epithelial–mesenchymal transition after kidney injury
PMCID: Pubmed No.:27579669
Doxycycline Attenuates Leptospira-Induced IL-1β by Suppressing NLRP3 Inflammasome Priming
PMCID: Pubmed No.:28791016
Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice
PMCID: Pubmed No.:29203196
AEG‐1 induces gastric cancer metastasis by upregulation of eIF4E expression
PMCID: Pubmed No.:28661037
Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF‐1 expression and DNA methylation
PMCID: Pubmed No.:28239993
17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway
PMCID: Pubmed No.:25403930
Alteration of Cholinergic Anti‐Inflammatory Pathway in Rat With Ischemic Cardiomyopathy–Modified Electrophysiological Function of Heart
PMCID: Pubmed No.:28928157
UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment
PMCID: Pubmed No.:28540657
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis
PMCID: Pubmed No.:26676572
Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation in high-fat-diet induced mice
PMCID: Pubmed No.:29024899
Melatonin‐induced increase of lipid droplets accumulation and in vitro maturation in porcine oocytes is mediated by mitochondrial quiescence
PMCID: Pubmed No.:28240360
Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose
PMCID: Pubmed No.:27318675
Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences
PMCID: Pubmed No.:26374551
Hypothalamic POMC expression is required for peripheral insulin action on hepatic gluconeogenesis through regulating STAT3 in sepsis rats
PMCID: Pubmed No.:29285858
Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
PMCID: Pubmed No.:29205806
Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes
PMCID: Pubmed No.:26113535
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein
PMCID: Pubmed No.:26444754
HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway
PMCID: Pubmed No.:26507311
Lithium alleviates neurotoxic prion peptide-induced synaptic damage and neuronal death partially by the upregulation of nuclear target REST and the restoration of Wnt signaling
PMCID: Pubmed No.:28545972
Targeted inhibition of RAGE reduces amyloid-β influx across the blood-brain barrier and improves cognitive deficits in db/db mice
PMCID: Pubmed No.:29248482
Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium
PMCID: Pubmed No.:27622883
Mangiferin protects mitochondrial function by preserving mitochondrial hexokinase-II in vessel endothelial cells
PMCID: Pubmed No.:28478227
CysLT1R downregulation reverses intracerebroventricular streptozotocin-induced memory impairment via modulation of neuroinflammation in mice
PMCID: Pubmed No.:27720931
Active vitamin D deficiency mediated by extracellular calcium and phosphorus results in male infertility in young mice
PMCID: Pubmed No.:25370849
Bone marrow mesenchymal stromal cells ameliorate angiogenesis and renal damage via promoting PI3k-Akt signaling pathway activation in vivo
PMCID: Pubmed No.:27210720
Cholecystokinin-8 inhibits methamphetamine-induced neurotoxicity via an anti-oxidative stress pathway
PMCID: Pubmed No.:27565679
Montelukast ameliorates streptozotocin-induced cognitive impairment and neurotoxicity in mice
PMCID: Pubmed No.:27702591
Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy
PMCID: Pubmed No.:28986232
Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy
PMCID: Pubmed No.:26547529
CERS2 Suppresses Tumor Cell Invasion and is Associated with Decreased V‐ATPase and MMP‐2/MMP‐9 Activities in Breast Cancer
PMCID: Pubmed No.:25213553
Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury
PMCID: Pubmed No.:28424621
HucMSC exosome-transported 14-3-3ζ prevents the injury of cisplatin to HK-2 cells by inducing autophagy in vitro
PMCID: Pubmed No.:28943243
MicroRNA-222 Controls Human Pancreatic Cancer Cell Line Capan-2 Proliferation by P57 Targeting
PMCID: Pubmed No.:26535064
Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy
PMCID: Pubmed No.:28545667
Yulangsan polysaccharide improves redox homeostasis and immune impairment in D-galactose-induced mimetic aging
PMCID: Pubmed No.:25920068
Quercetin inhibits renal cyst growth in vitro and via parenteral injection in a polycystic kidney disease mouse model
PMCID: Pubmed No.:29215110
Silence of long noncoding RNA PANDAR switches low-dose curcumin-induced senescence to apoptosis in colorectal cancer cells
PMCID: Pubmed No.:28176943
Antitumor and anti-metastatic mechanisms of Rhizoma paridis saponins in Lewis mice
PMCID: Pubmed No.:29148169
Missense mutations in the signal peptide of the porcine GH gene affect cellular synthesis and secretion
PMCID: Pubmed No.:26941166
lncRNA H19 regulates epithelial–mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA
PMCID: Pubmed No.:28779971
Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication
PMCID: Pubmed No.:26515789
Syndecan-4 Signaling Is Required for Exercise-Induced Cardiac Hypertrophy
PMCID: Pubmed No.:26835698
Etomidate Mitigates Lipopolysaccharide-Induced CD14 and TREM-1 Expression, NF-κB Activation, and Pro-inflammatory Cytokine Production in Rat Macrophages
PMCID: Pubmed No.:26383906
Zeaxanthin improves diabetes-induced cognitive deficit in rats through activiting PI3K/AKT signaling pathway
PMCID: Pubmed No.:28599877
Neuronal Soluble Fas Ligand Drives M1‐Microglia Polarization after Cerebral Ischemia
PMCID: Pubmed No.:27283206
Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver
PMCID: Pubmed No.:26884719
Acute liver failure impairs function and expression of breast cancer‐resistant protein (BCRP) at rat blood–brain barrier partly via ammonia‐ROS‐ERK1/2 activation
PMCID: Pubmed No.:27168176
Neuroprotective effect of picroside II in brain injury in mice
PMCID: Pubmed No.:28078024
Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin αVβ6 signaling
PMCID: Pubmed No.:28804548
Quantitative proteomics analysis to identify diffuse axonal injury biomarkers in rats using iTRAQ coupled LC–MS/MS
PMCID: Pubmed No.:26710722
Lipopolysaccharide derived from the digestive tract provokes oxidative stress in the liver of dairy cows fed a high-grain diet
PMCID: Pubmed No.:27865500
Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways
PMCID: Pubmed No.:28280123
IGF-1/IGF-1R/ hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla
PMCID: Pubmed No.:27833148
A variation in KCNQ1 gene is associated with repaglinide efficacy on insulin resistance in Chinese Type 2 Diabetes Mellitus Patients
PMCID: Pubmed No.:27857189
Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats
PMCID: Pubmed No.:28300221
MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells
PMCID: Pubmed No.:27250340
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats
PMCID: Pubmed No.:27453548
Abnormally activated one-carbon metabolic pathway is associated with mtDNA hypermethylation and mitochondrial malfunction in the oocytes of polycystic gilt ovaries
PMCID: Pubmed No.:26758245
Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα and cell-cycle-driving proteins
PMCID: Pubmed No.:26795955
P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi - 1 Deficiency
PMCID: Pubmed No.:28790310
Chronic Noise Exposure Acts Cumulatively to Exacerbate Alzheimer’s Disease-Like Amyloid-β Pathology and Neuroinflammation in the Rat Hippocampus
PMCID: Pubmed No.:26251361
Anti-aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency
PMCID: Pubmed No.:26370922
Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation
PMCID: Pubmed No.:26643367
Curcumin attenuates high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS
PMCID: Pubmed No.:26838071
Thymic derived iPs cells can be differentiated into cardiomyocytes
PMCID: Pubmed No.:25961536
NOK mediates glycolysis and nuclear PDC associated histone acetylation
PMCID: Pubmed No.:28410146
Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia/reperfusion injury through AMPK activation-mediated mitochondrial fission
PMCID: Pubmed No.:27869201
Hypoxia-induced vasculogenic mimicry formation in human colorectal cancer cells: Involvement of HIF-1a, Claudin-4, and E-cadherin and Vimentin
PMCID: Pubmed No.:27869227
Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway
PMCID: Pubmed No.:28282971
Inhibition of melanogenesis by jineol from Scolopendra subspinipes mutilans via MAP-Kinase mediated MITF downregulation and the proteasomal degradation of tyrosinase
PMCID: Pubmed No.:28393917
Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways
PMCID: Pubmed No.:28429775
A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2
PMCID: Pubmed No.:27145860
An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis
PMCID: Pubmed No.:27215610
Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment
PMCID: Pubmed No.:27373231
Effect of low-level mechanical vibration on osteogenesis and osseointegration of porous titanium implants in the repair of long bone defects
PMCID: Pubmed No.:26601709
Proteomic analysis of sheep primary testicular cells infected with bluetongue virus
PMCID: Pubmed No.:26989863
Stimulation of nitric oxide production contributes to the antiplatelet and antithrombotic effect of new peptide pENW (pGlu-Asn-Trp)
PMCID: Pubmed No.:26028472
Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo
PMCID: Pubmed No.:28364627
The protective effect of CDDO-Me on lipopolysaccharide-induced acute lung injury in mice
PMCID: Pubmed No.:25614226
Esculentoside A exerts anti-inflammatory activity in microglial cells
PMCID: Pubmed No.:28843178
Hyaluronan ameliorates LPS-induced acute lung injury in mice via Toll-like receptor (TLR) 4-dependent signaling pathways
PMCID: Pubmed No.:26321117
Activation of ephrinB–EphB receptor signalling in rat spinal cord contributes to maintenance of diabetic neuropathic pain
PMCID: Pubmed No.:27461472
miR-103 promotes 3T3-L1 cell adipogenesis through AKT/mTOR signal pathway with its target being MEF2D
PMCID: Pubmed No.:25400071
Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis
PMCID: Pubmed No.:26836165
Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells
PMCID: Pubmed No.:25394466
miR-34c plays a role of tumor suppressor in HEC‑1-B cells by targeting E2F3 protein
PMCID: Pubmed No.:25846116
Knockdown of RhoA expression alters ovarian cancer biological behavior in vitro and in nude mice
PMCID: Pubmed No.:26035556
Bcl-xL Genetic Modification Enhanced the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in the Treatment of Heart Infarction
PMCID: Pubmed No.:26074971
miR-135b, upregulated in breast cancer, promotes cell growth and disrupts the cell cycle by regulating LATS2
PMCID: Pubmed No.:26934863
Carnosic acid attenuates neuropathic pain in rat through the activation of spinal sirtuin1 and down-regulation of p66shc expression
PMCID: Pubmed No.:26804443
The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy
PMCID: Pubmed No.:29277549
Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway
PMCID: Pubmed No.:28501572
Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia
PMCID: Pubmed No.:25661534
Exosomes from Human Umbilical Cord Mesenchymal Stem Cells: Identification, Purification, and Biological Characteristics
PMCID: Pubmed No.:28105054
Synergistic Neuroprotective Effects of Two Herbal Ingredients via CREB-Dependent Pathway
PMCID: Pubmed No.:27729863
Inhibition of lung cancer in diethylnitrosamine‐induced mice by Rhizoma paridis saponins
PMCID: Pubmed No.:27991692
Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins
PMCID: Pubmed No.:26196122
Human Umbilical Cord Mesenchymal Stem Cells Protect Against SCA3 by Modulating the Level of 70 kD Heat Shock Protein
PMCID: Pubmed No.:28667374
Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria
PMCID: Pubmed No.:26202631
Mangiferin Attenuates Renal Fibrosis Through Down‐Regulation of Osteopontin in Diabetic Rats
PMCID: Pubmed No.:25380391
Effective treatment with combination of peripheral 5‐hydroxytryptamine synthetic inhibitor and 5‐hydroxytryptamine 2 receptor antagonist on glucocorticoid‐induced whole‐body insulin resistance with hyperglycemia
PMCID: Pubmed No.:27177506
Important role of 5‐hydroxytryptamine in glucocorticoid‐induced insulin resistance in liver and intra‐abdominal adipose tissue of rats
PMCID: Pubmed No.:26816599
SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis
PMCID: Pubmed No.:27470548
Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells
PMCID: Pubmed No.:27133064
Roles of Pannexin-1 Channels in Inflammatory Response through the TLRs/NF-Kappa B Signaling Pathway Following Experimental Subarachnoid Hemorrhage in Rats
PMCID: Pubmed No.:28634441
Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring
PMCID: Pubmed No.:28091351
Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2–ARE Pathway
PMCID: Pubmed No.:28066165
Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
PMCID: Pubmed No.:36500466
Withanolides isolated from Nicandra physaloides protect liver cells against oxidative stress-induced damage
PMCID: Pubmed No.:30414878
Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway
PMCID: Pubmed No.:27259983
Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signaling pathway
PMCID: Pubmed No.:28562206
LPS-induced CXCR4-dependent migratory properties and a mesenchymal-like phenotype of colorectal cancer cells
PMCID: Pubmed No.:26745593
Esculentoside A suppresses lipopolysaccharide-induced pro-inflammatory molecule production partially by casein kinase 2
PMCID: Pubmed No.:28027904
YiQiFuMai Powder Injection ameliorates the oxygen-glucose deprivation-induced brain microvascular endothelial barrier dysfunction associated with the NF-κB and ROCK1/MLC signaling pathways
PMCID: Pubmed No.:26915982
Chotosan improves Aβ1–42-induced cognitive impairment and neuroinflammatory and apoptotic responses through the inhibition of TLR-4/NF-κB signaling in mice
PMCID: Pubmed No.:26994819
Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid
PMCID: Pubmed No.:26226437
Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats
PMCID: Pubmed No.:28341485
Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis
PMCID: Pubmed No.:27601167
Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease
PMCID: Pubmed No.:25497709
Drosophila miR-964 modulates Toll signaling pathway in response to bacterial infection
PMCID: Pubmed No.:28823799
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway
PMCID: Pubmed No.:27252679
Involvement of pregnane X receptor in the suppression of carboxylesterases by metformin in vivo and in vitro, mediated by the activation of AMPK and JNK signaling pathway
PMCID: Pubmed No.:28238946
CRHR1 Mediates the Up-Regulation of Synapsin I Induced by Nesfatin-1 Through ERK 1/2 Signaling in SH-SY5Y Cells
PMCID: Pubmed No.:28608000
IL-33 Expression in the Cerebral Cortex Following Experimental Subarachnoid Hemorrhage in Rats
PMCID: Pubmed No.:25417195
Expression of Cytoplasmic Gelsolin in Rat Brain After Experimental Subarachnoid Hemorrhage
PMCID: Pubmed No.:25744577
Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study
PMCID: Pubmed No.:25744577
Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720
PMCID: Pubmed No.:26099903
Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice
PMCID: Pubmed No.:28101381
Bmi-1 plays a critical role in the protection from acute tubular necrosis by mobilizing renal stem/progenitor cells
PMCID: Pubmed No.:27871857
Gastrin-releasing peptide induces monocyte adhesion to vascular endothelium by upregulating endothelial adhesion molecules
PMCID: Pubmed No.:28093230
Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure
PMCID: Pubmed No.:28237360
MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing
PMCID: Pubmed No.:28733031
NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression
PMCID: Pubmed No.:26299924
MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel
PMCID: Pubmed No.:26299922
Radiosensitization of esophageal carcinoma cells by knockdown of RNF2 expression
PMCID: Pubmed No.:26936624
Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo
PMCID: Pubmed No.:28627695
Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury
PMCID: Pubmed No.:28419832
FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells
PMCID: Pubmed No.:25939952
Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non–Small-Cell Lung Cancer Cells
PMCID: Pubmed No.:25979647
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection
PMCID: Pubmed No.:28529930
NOAD, a novel nitric oxide donor, induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells
PMCID: Pubmed No.:26001517
Inhibition of green tea polyphenol EGCG((−)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical wnt/β-catenin signalling pathway
PMCID: Pubmed No.:27338284
Meat proteins had different effects on oligopeptide transporter PEPT1 in the small intestine of young rats
PMCID: Pubmed No.:27455889
α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines
PMCID: Pubmed No.:28822990
Comparative analysis of the serum proteome for biomarker discovery to reveal hepatotoxicity induced by iron ion radiation in mice
PMCID: Pubmed No.:27815023
Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms
PMCID: Pubmed No.:29223540
Knockdown of hippocampal cysteinyl leukotriene receptor 1 prevents depressive behavior and neuroinflammation induced by chronic mild stress in mice
PMCID: Pubmed No.:26546369
Silencing of GP73 inhibits invasion and metastasis via suppression of epithelial-mesenchymal transition in hepatocellular carcinoma
PMCID: Pubmed No.:28075476
Stimulation of peroxisome proliferator-activated receptor γ inhibits estrogen receptor α transcriptional activity in endometrial carcinoma cells
PMCID: Pubmed No.:25592200
EVI5 is a novel independent prognostic predictor in hepatocellular carcinoma after radical hepatectomy
PMCID: Pubmed No.:28765910
Huaier extract enhances the treatment efficacy of paclitaxel in breast cancer cells via the NF-κB/IκBα pathway
PMCID: Pubmed No.:29039556
Isoliquiritigenin inhibits the proliferation and induces the differentiation of human glioma stem cells
PMCID: Pubmed No.:29251326
α-Lipoic acid attenuates LPS-induced liver injury by improving mitochondrial function in association with GR mitochondrial DNA occupancy
PMCID: Pubmed No.:26133658
Neuroprotective Effect of Sodium Butyrate against Cerebral Ischemia/Reperfusion Injury in Mice
PMCID: Pubmed No.:26064905
Regulatory role of miR-125a/b in the suppression by selenium of cadmium-induced apoptosis via the mitochondrial pathway in LLC-PK1 cells
PMCID: Pubmed No.:26607349
Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway
PMCID: Pubmed No.:28734031
Phosphorylated heat shock protein 27 promotes lipid clearance in hepatic cells through interacting with STAT3 and activating autophagy
PMCID: Pubmed No.:27185187
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ
PMCID: Pubmed No.:25748049
Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells
PMCID: Pubmed No.:26968633
Bmi1 plays an important role in dentin and mandible homeostasis by maintaining redox balance
PMCID: Pubmed No.:27904674
Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury
PMCID: Pubmed No.:28386319
Pyrroloquinoline quinone prevents testosterone deficiency-induced osteoporosis by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption
PMCID: Pubmed No.:28386349
The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion
PMCID: Pubmed No.:28479214
The effect of monascin on hematoma clearance and edema after intracerebral hemorrhage in rats
PMCID: Pubmed No.:28655601
Heat Stress Reduces Sperm Motility via Activation of Glycogen Synthase Kinase-3α and Inhibition of Mitochondrial Protein Import
PMCID: Pubmed No.:29018353
Mogroside IVE attenuates experimental liver fibrosis in mice and inhibits HSC activation through downregulating TLR4-mediated pathways
PMCID: Pubmed No.:29268190
Bergapten prevents lipopolysaccharide-induced inflammation in RAW264.7 cells through suppressing JAK/STAT activation and ROS production and increases the survival rate of mice after LPS challenge
PMCID: Pubmed No.:28511114
Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways
PMCID: Pubmed No.:27261558
Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing α-aminophosphonates
PMCID: Pubmed No.:24262379
MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264.7 macrophages
PMCID: Pubmed No.:26800097
Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway
PMCID: Pubmed No.:26881857
Role of NLRC5 in progression and reversal of hepatic fibrosis
PMCID: Pubmed No.:26806094
HZ-6d targeted HERC5 to regulate p53 ISGylation in human hepatocellular carcinoma
PMCID: Pubmed No.:28919514
X-11-5-27, a daidzein derivative, inhibits NLRP3 inflammasome activity via promoting autophagy
PMCID: Pubmed No.:28942022
Up-regulation of Tight-Junction Proteins by p38 Mitogen-Activated Protein Kinase/p53 Inhibition Leads to a Reduction of Injury to the Intestinal Mucosal Barrier in Severe Acute Pancreatitis
PMCID: Pubmed No.:27171513
RAGE-NF-κB-PPARγ Signaling is Involved in AGEs-Induced Upregulation of Amyloid-β Influx Transport in an In Vitro BBB Model
PMCID: Pubmed No.:28871412
The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke
PMCID: Pubmed No.:28916471
MicroRNA-150 negatively regulates the function of CD4+ T cells through AKT3/Bim signaling pathway
PMCID: Pubmed No.:27329362
MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes
PMCID: Pubmed No.:26934991
Tetramethylpyrazine phosphate and borneol combination therapy synergistically attenuated ischemia-reperfusion injury of the hypothalamus and striatum via regulation of apoptosis and autophagy in a rat model
PMCID: Pubmed No.:29218081
Inhibition of SENP3 by lentivirus induces suppression of apoptosis in experimental subarachnoid hemorrhage in rats
PMCID: Pubmed No.:26151898
Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway
PMCID: Pubmed No.:26475978
Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice
PMCID: Pubmed No.:28499972
Regulation of RAW 264.7 cell-mediated immunity by polysaccharides from Agaricus blazei Murill via the MAPK signal transduction pathway
PMCID: Pubmed No.:28322382
Lipopolysaccharide markedly changes glucose metabolism and mitochondrial function in the longissimus muscle of pigs
PMCID: Pubmed No.:26863995
Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis
PMCID: Pubmed No.:25986850
Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway
PMCID: Pubmed No.:26316699
Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway
PMCID: Pubmed No.:29033541
Comparative proteomics reveals the underlying toxicological mechanism of low sperm motility induced by iron ion radiation in mice
PMCID: Pubmed No.:27460355
Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes
PMCID: Pubmed No.:26257270
Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome
PMCID: Pubmed No.:37777764
Blueberry anthocyanins extract inhibits acrylamide-induced diverse toxicity in mice by preventing oxidative stress and cytochrome P450 2E1 activation
PMCID: Pubmed No.:32982731
Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation
PMCID: Pubmed No.:26049867
Apelin-13 as a novel target for intervention in secondary injury after traumatic brain injury
PMCID: Pubmed No.:27630697
Compound edaravone alleviates lipopolysaccharide (LPS)-induced acute lung injury in mice
PMCID: Pubmed No.:28552343
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways
PMCID: Pubmed No.:28648405
Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and -9
PMCID: Pubmed No.:29065966
MALAT1 promoted invasiveness of gastric adenocarcinoma
PMCID: Pubmed No.:28077118
Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway
PMCID: Pubmed No.:27592453
Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice
PMCID: Pubmed No.:26943960
Protective effects of Shanxi aged vinegar against hydrogen peroxide-induced oxidative damage in LO2 cells through Nrf2-mediated antioxidant responses
PMCID: Pubmed No.:37200790
Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries
PMCID: Pubmed No.:28494840
Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy
PMCID: Pubmed No.:27565710
l-Theanine attenuates cadmium-induced neurotoxicity through the inhibition of oxidative damage and tau hyperphosphorylation
PMCID: Pubmed No.:27649883
Icariin alters the expression of glucocorticoid receptor, FKBP5 and SGK1 in rat brains following exposure to chronic mild stress
PMCID: Pubmed No.:27221032
iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells
PMCID: Pubmed No.:26935776
miR-30a inhibits the biological function of breast cancer cells by targeting Notch1
PMCID: Pubmed No.:28765900
MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/β-catenin pathway
PMCID: Pubmed No.:27289031
Daphnetin reduces endotoxin lethality in mice and decreases LPS-induced inflammation in Raw264.7 cells via suppressing JAK/STATs activation and ROS production
PMCID: Pubmed No.:28409189
2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d‐glucoside protects human umbilical vein endothelial cells against lysophosphatidylcholine‐induced apoptosis by upregulating superoxide dismutase and glutathione peroxidase
PMCID: Pubmed No.:25382724
TSG attenuates LPC‐induced endothelial cells inflammatory damage through notch signaling inhibition
PMCID: Pubmed No.:26662286
miR-375 exhibits a more effective tumor-suppressor function in laryngeal squamous carcinoma cells by regulating KLF4 expression compared with simple co-transfection of miR-375 and miR-206
PMCID: Pubmed No.:27279635
Downregulation of miR-129-2 by promoter hypermethylation regulates breast cancer cell proliferation and apoptosis
PMCID: Pubmed No.:26935022
Deubiquitinase USP9X promotes cell migration, invasion and inhibits apoptosis of human pancreatic cancer
PMCID: Pubmed No.:29130109
Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs
PMCID: Pubmed No.:26779540
Increased Expression of Caspase-12 After Experimental Subarachnoid Hemorrhage
PMCID: Pubmed No.:27718045
Ursolic Acid Ameliorates Early Brain Injury After Experimental Traumatic Brain Injury in Mice by Activating the Nrf2 Pathway
PMCID: Pubmed No.:27734181
dl -3- n -Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway
PMCID: Pubmed No.:28214984
Folic Acid Protected Neural Cells Against Aluminum-Maltolate-Induced Apoptosis by Preventing miR-19 Downregulation
PMCID: Pubmed No.:27113042
Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway
PMCID: Pubmed No.:26518113
Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives
PMCID: Pubmed No.:27473965
Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways
PMCID: Pubmed No.:26614458
C-reactive protein inhibits high-molecular-weight adiponectin expression in 3T3-L1 adipocytes via PI3K/Akt pathway
PMCID: Pubmed No.:26812237
SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment
PMCID: Pubmed No.:26043699
Annosquacin B induces mitochondrial apoptosis in multidrug resistant human breast cancer cell line MCF-7/ADR through selectively modulating MAPKs pathways
PMCID: Pubmed No.:27450387
Helicobacter pylori-infected MSCs acquire a pro-inflammatory phenotype and induce human gastric cancer migration by promoting EMT in gastric cancer cells
PMCID: Pubmed No.:26870232
ONTD induces growth arrest and apoptosis of human hepatoma Bel-7402 cells though a peroxisome proliferator-activated receptor γ-dependent pathway
PMCID: Pubmed No.:28834734
Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways
PMCID: Pubmed No.:27572279
microRNA‑99a inhibits cell proliferation, colony formation ability, migration and invasion by targeting fibroblast growth factor receptor 3 in prostate cancer
PMCID: Pubmed No.:25352177
Long non‑coding RNA‑GAS5 acts as a tumor suppressor in bladder transitional cell carcinoma via regulation of chemokine (C‑C motif) ligand 1 expression
PMCID: Pubmed No.:26548923
Icariin ameliorates dexamethasone‑induced bone deterioration in an experimental mouse model via activation of microRNA‑186 inhibition of cathepsin K
PMCID: Pubmed No.:29257214
Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut‐brain axis
PMCID: Pubmed No.:29193450
Inhibition of IRF8 Negatively Regulates Macrophage Function and Impairs Cutaneous Wound Healing
PMCID: Pubmed No.:27709315
Syndecan-4 regulates the bFGF-induced chemotactic migration of endothelial cells
PMCID: Pubmed No.:27541034
Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis
PMCID: Pubmed No.:27035418
Tougu Xiaotong formula induces chondrogenic differentiation in association with transforming growth factor-β1 and promotes proliferation in bone marrow stromal cells
PMCID: Pubmed No.:25543835
Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide
PMCID: Pubmed No.:25955519
Transgenic expression of ephrinB2 in periodontal ligament stem cells (PDLSCs) modulates osteogenic differentiation via signaling crosstalk between ephrinB2 and EphB4 in PDLSCs and between PDLSCs and pre‐osteoblasts within co‐culture
PMCID: Pubmed No.:27763659
Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats
PMCID: Pubmed No.:26640758
Lipopolysaccharide significantly influences the hepatic triglyceride metabolism in growing pigs
PMCID: Pubmed No.:26121977
Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice
PMCID: Pubmed No.:26758315
Panaxatriol saponins promotes angiogenesis and enhances cerebral perfusion after ischemic stroke in rats
PMCID: Pubmed No.:28114983
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase
PMCID: Pubmed No.:27545328
Arctigenin suppresses transforming growth factor-β1-induced expression of monocyte chemoattractant protein-1 and the subsequent epithelial–mesenchymal transition through reactive oxygen species-dependent ERK/NF-κB signaling pathway in renal tubular epithe
PMCID: Pubmed No.:25968940
Bursopentin (BP5) Protects Dendritic Cells from Lipopolysaccharide-Induced Oxidative Stress for Immunosuppression
PMCID: Pubmed No.:25659113
miR-101 Suppresses Vascular Endothelial Growth Factor C That Inhibits Migration and Invasion and Enhances Cisplatin Chemosensitivity of Bladder Cancer Cells
PMCID: Pubmed No.:25658842
In Ovo Injection of Betaine Affects Hepatic Cholesterol Metabolism through Epigenetic Gene Regulation in Newly Hatched Chicks
PMCID: Pubmed No.:25860502
Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in rats
PMCID: Pubmed No.:29133197
FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide
PMCID: Pubmed No.:29128799
Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway
PMCID: Pubmed No.:27780244
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
PMCID: Pubmed No.:28182650
Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease
PMCID: Pubmed No.:26974541
Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage
PMCID: Pubmed No.:27725151
Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats
PMCID: Pubmed No.:26210617
Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway
PMCID: Pubmed No.:27761760
PPARδ agonist GW0742 ameliorates Aβ 1–42 -induced hippocampal neurotoxicity in mice
PMCID: Pubmed No.:26864581
Syndecan-4 shedding impairs macrovascular angiogenesis in diabetes mellitus
PMCID: Pubmed No.:27018253
Sulfiredoxin-1 Attenuates Oxidative Stress via Nrf2/ARE Pathway and 2-Cys Prdxs After Oxygen-Glucose Deprivation in Astrocytes
PMCID: Pubmed No.:25407820
Rho Kinase Inhibitor, Fasudil, Attenuates Contrast‐induced Acute Kidney Injury
PMCID: Pubmed No.:28929640
The possible role of liver kinase B1 in hydroquinone‐induced toxicity of murine fetal liver and bone marrow hematopoietic stem cells
PMCID: Pubmed No.:25534963
Expression of Transcription Factor FOXO3a is Decreased in Patients with Ulcerative Colitis
PMCID: Pubmed No.:26481742
Heparin-Binding Epidermal Growth Factor-Like Growth Factor Enhances Aquaporin 3 Expression and Function During Mouse Embryo Implantation
PMCID: Pubmed No.:27436370
Parasympathectomy increases resting salivary secretion in normal and irradiated submandibular glands of rats
PMCID: Pubmed No.:28084660
IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations
PMCID: Pubmed No.:28612255
LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats
PMCID: Pubmed No.:27533766
The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation
PMCID: Pubmed No.:28424976
The Synergic Effect of Tetramethylpyrazine Phosphate and Borneol for Protecting Against Ischemia Injury in Cortex and Hippocampus Regions by Modulating Apoptosis and Autophagy
PMCID: Pubmed No.:28779236
Effect of β‐catenin silencing in overcoming radioresistance of head and neck cancer cells by antagonizing the effects of AMPK on Ku70/Ku80
PMCID: Pubmed No.:26713771
The angiogenic variation of skeletal site-specific human BMSCs from same alveolar cleft patients: a comparative study
PMCID: Pubmed No.:26846721
Human amnion mesenchymal stem cells promote proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells
PMCID: Pubmed No.:25432786
Depleted aldehyde dehydrogenase 1A1 (ALDH1A1) reverses cisplatin resistance of human lung adenocarcinoma cell A549/DDP
PMCID: Pubmed No.:27813328
MicroRNA-9 regulates cardiac fibrosis by targeting PDGFR-β in rats
PMCID: Pubmed No.:26896308
miR-31 promotes proliferation of colon cancer cells by targeting E2F2
PMCID: Pubmed No.:25362258
Phosphoglycerate mutase 1 knockdown inhibits prostate cancer cell growth, migration, and invasion
PMCID: Pubmed No.:29271400
Neuroprotection by peripheral nerve electrical stimulation and remote postconditioning against acute experimental ischaemic stroke
PMCID: Pubmed No.:25819636
Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos
PMCID: Pubmed No.:27837686
HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells
PMCID: Pubmed No.:27660075
Investigations of 99mTc-labeled glucarate as a SPECT radiotracer for non-small cell lung cancer (NSCLC) and potential tumor uptake mechanism
PMCID: Pubmed No.:29467852
Expression Profiles of IGF-1R Gene and Polymorphisms of its Regulatory Regions in Different Pig Breeds
PMCID: Pubmed No.:27229719
Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9
PMCID: Pubmed No.:26359917
5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages
PMCID: Pubmed No.:28071183
Tumor‑suppressing effects of microRNA‑429 in human renal cell carcinoma via the downregulation of Sp1
PMCID: Pubmed No.:27698878
Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain
PMCID: Pubmed No.:28521486
Effect of hyperthermic CO2-treated dendritic cell-derived exosomes on the human gastric cancer AGS cell line
PMCID: Pubmed No.:26170979
Molecular Characterization of Equine APRIL and its Expression Analysis During the Adipogenic Differentiation of Equine Adipose-Derived Stem Cell In Vitro
PMCID: Pubmed No.:27565870
Polypeptides from the Skin of Rana chensinensis Exert the Antioxidant and Antiapoptotic Activities on HaCaT Cells
PMCID: Pubmed No.:27385409
Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis
PMCID: Pubmed No.:27057539
Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice
PMCID: Pubmed No.:29075638
Involvement of the PI3K/Akt/NF-κB Signaling Pathway in the Attenuation of Severe Acute Pancreatitis-Associated Acute Lung Injury by Sedum sarmentosum Bunge Extract
PMCID: Pubmed No.:29359164
Melatonin reduces hypoxic-ischaemic (HI) induced autophagy and apoptosis: An in vivo and in vitro investigation in experimental models of neonatal HI brain injury
PMCID: Pubmed No.:28341477
The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage
PMCID: Pubmed No.:27343409
Dietary betaine supplementation in hens modulates hypothalamic expression of cholesterol metabolic genes in F1 cockerels through modification of DNA methylation
PMCID: Pubmed No.:29247843
Leptin treatment prevents long-term abnormalities in cognition, seizure threshold, hippocampal mossy fiber sprouting and ZnT3/CB-D28k expression in a rat developmental “twist” seizure model
PMCID: Pubmed No.:29287786
Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction
PMCID: Pubmed No.:28691024
Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo
PMCID: Pubmed No.:26491665
Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/β-catenin pathway in rats
PMCID: Pubmed No.:29138567
Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats
PMCID: Pubmed No.:29299199
Whole Body Vibration Improves Insulin Resistance in db/db Mice: Amelioration of Lipid Accumulation and Oxidative Stress
PMCID: Pubmed No.:26945578
H2S inhibits apo(a) expression and secretion through PKCα/FXR and Akt/HNF4α pathways in HepG2 cells
PMCID: Pubmed No.:27298021
Phenotype transformation of immortalized NCM460 colon epithelial cell line by TGF-β1 is associated with chromosome instability
PMCID: Pubmed No.:27401062
Silencing thioredoxin1 exacerbates damage of astrocytes exposed to OGD/R by aggravating apoptosis through the Actin–Ras2–cAMP–PKA pathway
PMCID: Pubmed No.:29073813
Resveratrol inhibits phosphorylation within the signal transduction and activator of transcription 3 signaling pathway by activating sirtuin 1 in SW1353 chondrosarcoma cells
PMCID: Pubmed No.:27484919
VPA and MEL induce apoptosis by inhibiting the Nrf2-ARE signaling pathway in TMZ-resistant U251 cells
PMCID: Pubmed No.:28560379
Effects of p53 on aldosterone-induced mesangial cell apoptosis in vivo and in vitro
PMCID: Pubmed No.:27109859
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism
PMCID: Pubmed No.:25394852
Astragalus and Paeoniae Radix Rubra extract (APE) inhibits hepatic stellate cell activation by modulating transforming growth factor-β/smad pathway
PMCID: Pubmed No.:25435153
Protein kinase Cα stimulates hypoxia‑induced pulmonary artery smooth muscle cell proliferation in rats through activating the extracellular signal‑regulated kinase 1/2 pathway
PMCID: Pubmed No.:28901444
Bone marrow-derived mesenchymal stem cells inhibit the proliferation of hepatic stellate cells by inhibiting the transforming growth factor β pathway
PMCID: Pubmed No.:26458849
The Inhibitory Effect of Eplerenone on Cell Proliferation in the Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction
PMCID: Pubmed No.:28402979
Glioma targeting peptide in combination with the P53 C terminus inhibits glioma cell proliferation in vitro
PMCID: Pubmed No.:28879517
5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats
PMCID: Pubmed No.:27133527
Sarsasapogenin suppresses Aβ overproduction induced by high glucose in HT-22 cells
PMCID: Pubmed No.:29275517
Erythroblast transformation-specific 2 correlates with vascular smooth muscle cell apoptosis in rat heterotopic heart transplantation model
PMCID: Pubmed No.:27621856
Prenatal betaine exposure modulates hypothalamic expression of cholesterol metabolic genes in cockerels through modifications of DNA methylation
PMCID: Pubmed No.:27965408
YGS40, an active fraction of Yi-Gan San, reduces hydrogen peroxide-induced apoptosis in PC12 cells
PMCID: Pubmed No.:26073340
Connective tissue growth factor induces tubular epithelial to mesenchymal transition through the activation of canonical Wnt signaling in vitro
PMCID: Pubmed No.:25296105
Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation
PMCID: Pubmed No.:27500692
Folate deprivation modulates the expression of autophagy- and circadian-related genes in HT-22 hippocampal neuron cells through GR-mediated pathway
PMCID: Pubmed No.:27133904
Short-Term Hypoxia Accelerates Bone Loss in Ovariectomized Rats by Suppressing Osteoblastogenesis but Enhancing Osteoclastogenesis
PMCID: Pubmed No.:27550548
Alpha-Lipoic Acid Alleviates Acute Inflammation and Promotes Lipid Mobilization During the Inflammatory Response in White Adipose Tissue of Mice
PMCID: Pubmed No.:27531126
Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells
PMCID: Pubmed No.:26055917
Silencing platelet‑derived growth factor receptor‑β enhances the radiosensitivity of C6 glioma cells in vitro and in vivo
PMCID: Pubmed No.:28693172
Effect of the p53α gene on the chemosensitivity of the H1299 human lung adenocarcinoma cell line
PMCID: Pubmed No.:28789357
Oncostatin M was associated with thrombosis in patients with atrial fibrillation
PMCID: Pubmed No.:28471981
Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose‑induced renal mesangial cells through cell cycle regulation and induction of apoptosis
PMCID: Pubmed No.:27572472
Ibuprofen attenuates nephropathy in streptozotocin‑induced diabetic rats
PMCID: Pubmed No.:27109015
Effect of vascular endothelial growth factor siRNA and wild‑type p53 co‑expressing plasmid in MDA‑MB‑231 cells
PMCID: Pubmed No.:26573068
Nano-microcapsule basic fibroblast growth factor combined with hypoxia-inducible factor-1 improves random skin flap survival in rats
PMCID: Pubmed No.:26707180
Human trypsin inhibitor reduces the apoptosis of lipopolysaccharide‑induced human kidney‑2 cells by promoting mitochondrial fusion
PMCID: Pubmed No.:28713932
Recombinant lentivirus with enhanced expression of caudal‑related homeobox protein 2 inhibits human colorectal cancer cell proliferation in vitro
PMCID: Pubmed No.:25847407
Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway
PMCID: Pubmed No.:28849038
Emodin promotes the arrest of human lymphoma Raji cell proliferation through the UHRF1‑DNMT3A‑∆Np73 pathways
PMCID: Pubmed No.:28901428
Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism
PMCID: Pubmed No.:27916377
The effects of porcine pulmonary surfactant on smoke inhalation injury
PMCID: Pubmed No.:26073349
Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells
PMCID: Pubmed No.:27240983
The Effects of Aqueous Extract from Nardostachys chinensis Batalin on Blood Pressure and Cardiac Hypertrophy in Two-Kidney One-Clip Hypertensive Rats
PMCID: Pubmed No.:29234388
Ibuprofen Attenuates Cardiac Fibrosis in Streptozotocin-Induced Diabetic Rats
PMCID: Pubmed No.:25896805
Particularly interesting Cys‑His‑rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture
PMCID: Pubmed No.:28101173
Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1
PMCID: Pubmed No.:28123507
Effects of Angelica dahurica on obesity and fatty liver in mice
PMCID: Pubmed No.:27667509
Anti-proliferative potential of Glucosamine in renal cancer cells via inducing cell cycle arrest at G0/G1 phase
PMCID: Pubmed No.:28558682
LFG-500, a newly synthesized flavonoid, induces apoptosis in human ovarian carcinoma SKOV3 cells with involvement of the reactive oxygen species-mitochondria pathway
PMCID: Pubmed No.:28587346
Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway
PMCID: Pubmed No.:25667611
Anti‑inflammatory effects of Fagopyrum cymosum administered as a potential drug for ulcerative colitis
PMCID: Pubmed No.:29201175
The Inhibitory Effect of Rhein on Proliferation of High Glucose-induced Mesangial Cell Through Cell Cycle Regulation and Induction of Cell Apoptosis
PMCID: Pubmed No.:27279717
Epicatechin Plus Treadmill Exercise are Neuroprotective Against Moderate-stage Amyloid Precursor Protein/Presenilin 1 Mice
PMCID: Pubmed No.:27279698
Maternal betaine supplementation during gestation modifies hippocampal expression of GR and its regulatory miRNAs in neonatal piglets
PMCID: Pubmed No.:26875838
Effect of Qingxinkaiqiao compound on cortical mRNA expression of the apoptosis-related genes Bcl-2, BAX, caspase-3, and Aβ in an Alzheimer's disease rat model
PMCID: Pubmed No.:29933535
Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma
PMCID: Pubmed No.:26191201
MicroRNA-221 promotes human non-small cell lung cancer cell H460 growth
PMCID: Pubmed No.:25932132
Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line
PMCID: Pubmed No.:26131123
Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway
PMCID: Pubmed No.:26550172
Role of WNT1-inducible-signaling pathway protein 1 in etoposide resistance in lung adenocarcinoma A549 cells
PMCID: Pubmed No.:26628978
Dexmedetomidine alleviates the spinal cord ischemia-reperfusion injury through blocking mast cell degranulation
PMCID: Pubmed No.:26628956
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
PMCID: Pubmed No.:27563814
ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway
PMCID: Pubmed No.:27588482
Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors
PMCID: Pubmed No.:27659532
Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy
PMCID: Pubmed No.:27708223
Potential role of Wnt/β-catenin signaling in blastic transformation of chronic myeloid leukemia: cross talk between β-catenin and BCR-ABL
PMCID: Pubmed No.:27817074
High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1
PMCID: Pubmed No.:27889764
Cytological study on the regulation of lymphocyte homing in the chicken spleen during LPS stimulation
PMCID: Pubmed No.:28061467
VEGF promotes cartilage angiogenesis by phospho-ERK1/2 activation of Dll4 signaling in temporomandibular joint osteoarthritis caused by chronic sleep disturbance in Wistar rats
PMCID: Pubmed No.:28147322
Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/ NF-κB signaling pathway after LPS treatment in neonatal rats
PMCID: Pubmed No.:28404943
Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus M1 by stimulating anti-viral immunity
PMCID: Pubmed No.:28445966
Effect of Y6, an epigallocatechin gallate derivative, on reversing doxorubicin drug resistance in human hepatocellular carcinoma cells
PMCID: Pubmed No.:28423656
EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells
PMCID: Pubmed No.:27231847
Osterix acetylation at K307 and K312 enhances its transcriptional activity and is required for osteoblast differentiation
PMCID: Pubmed No.:27250035
A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1
PMCID: Pubmed No.:27374176
Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling
PMCID: Pubmed No.:27367023
AIM2 inhibits autophagy and IFN-β production during M. bovis infection
PMCID: Pubmed No.:27409673
TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype
PMCID: Pubmed No.:27418133
ColXV promotes adipocyte differentiation via inhibiting DNA methylation and cAMP/PKA pathway in mice
PMCID: Pubmed No.:28947959
Pathological expression of tissue factor confers promising antitumor response to a novel therapeutic antibody SC1 in triple negative breast cancer and pancreatic adenocarcinoma
PMCID: Pubmed No.:28938620
Silencing of HMGA2 suppresses cellular proliferation, migration, invasion, and epithelial–mesenchymal transition in bladder cancer
PMCID: Pubmed No.:26684800
Axon guidance molecule semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma
PMCID: Pubmed No.:26755661
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway
PMCID: Pubmed No.:26943030
Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells
PMCID: Pubmed No.:27027340
Exosomes derived from gefitinib-treated EGFR-mutant lung cancer cells alter cisplatin sensitivity via up-regulating autophagy
PMCID: Pubmed No.:27029054
Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism
PMCID: Pubmed No.:27050279
miR-675-5p enhances tumorigenesis and metastasis of esophageal squamous cell carcinoma by targeting REPS2
PMCID: Pubmed No.:27120794
Focal adhesion kinase and paxillin promote migration and adhesion to fibronectin by swine skeletal muscle satellite cells
PMCID: Pubmed No.:27127174
Overexpression of HMGB3 protein promotes cell proliferation, migration and is associated with poor prognosis in urinary bladder cancer patients
PMCID: Pubmed No.:25647262
β-Elemene Reverses Chemoresistance of Breast Cancer via Regulating MDR-Related MicroRNA Expression
PMCID: Pubmed No.:25562151
Protective Effect of Spironolactone on Endothelial-to-Mesenchymal Transition in HUVECs via Notch Pathway
PMCID: Pubmed No.:25967959
Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome
PMCID: Pubmed No.:28938606
Laminarin counteracts diet-induced obesity associated with glucagon-like peptide-1 secretion
PMCID: Pubmed No.:29245916
Reduced expression of BMP3 contributes to the development of pulmonary fibrosis and predicts the unfavorable prognosis in IIP patients
PMCID: Pubmed No.:29113323
Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes
PMCID: Pubmed No.:29221131
Metformin treatment after the hypoxia-ischemia attenuates brain injury in newborn rats
PMCID: Pubmed No.:29088867
Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction
PMCID: Pubmed No.:26198575
miR-382 targeting PTEN-Akt axis promotes liver regeneration
PMCID: Pubmed No.:26636539
Dihydroartemisinin and Curcumin Synergistically Induce Apoptosis in SKOV3 Cells Via Upregulation of MiR-124 Targeting Midkine
PMCID: Pubmed No.:28934730
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling
PMCID: Pubmed No.:29285277
Osterix Decreases the Chemosensitivity of Breast Cancer Cells by Upregulating GALNT14
PMCID: Pubmed No.:29227978
Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth
PMCID: Pubmed No.:26124080
Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injury
PMCID: Pubmed No.:26055972
Salvianolic Acids for Injection (SAFI) promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice
PMCID: Pubmed No.:28887094
NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma
PMCID: Pubmed No.:32295623
Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
PMCID: Pubmed No.:29670091
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1
PMCID: Pubmed No.:33484341
Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation
PMCID: Pubmed No.:32473460
Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells
PMCID: Pubmed No.:36654154
The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists
PMCID: Pubmed No.:33754076
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation
PMCID: Pubmed No.:34589402
ATAD2 interacts with C/EBPβ to promote esophageal squamous cell carcinoma metastasis via TGF-β1/Smad3 signaling
PMCID: Pubmed No.:33757572
The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression
PMCID: Pubmed No.:31126313
HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling
PMCID: Pubmed No.:31785531
PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress
PMCID: Pubmed No.:32896721
NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
PMCID: Pubmed No.:34407403
A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial–Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer
PMCID: Pubmed No.:30796032
A synonymous mutation in IGF-1 impacts the transcription and translation process of gene expression
PMCID: Pubmed No.:34938600
Oncostatin M promotes hepatic progenitor cell activation and hepatocarcinogenesis via macrophage-derived tumor necrosis factor-α
PMCID: Pubmed No.:34102284
The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure
PMCID: Pubmed No.:32483446
Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury
PMCID: Pubmed No.:30237401
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4+ T cell apoptosis
PMCID: Pubmed No.:32375831
Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS
PMCID: Pubmed No.:34403364
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction
PMCID: Pubmed No.:34837851
Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis
PMCID: Pubmed No.:31367260
A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity
PMCID: Pubmed No.:33377656
Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway
PMCID: Pubmed No.:30735911
Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/Nrf2/Prx2/ASK1/P38 after traumatic brain injury in mice
PMCID: Pubmed No.:33326114
Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease
PMCID: Pubmed No.:29679667
The Neuroprotective Effect of Short Chain Fatty Acids Against Sepsis-Associated Encephalopathy in Mice
PMCID: Pubmed No.:33584734
CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses
PMCID: Pubmed No.:33603756
SIRT1 Promotes M2 Microglia Polarization via Reducing ROS-Mediated NLRP3 Inflammasome Signaling After Subarachnoid Hemorrhage.
PMCID: Pubmed No.:34899720
A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage
PMCID: Pubmed No.:34381441
Ceria Nanoparticles Fabricated with 6‐Aminohexanoic Acid that Overcome Systemic Inflammatory Response Syndrome
PMCID: Pubmed No.:30843374
Melatonin alleviates progression of uterine endometrial cancer by suppressing estrogen/ubiquitin C/SDHB-mediated succinate accumulation
PMCID: Pubmed No.:32061949
Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction
PMCID: Pubmed No.:31429767
1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
PMCID: Pubmed No.:30907059
Bone marrow derived mesenchymal stem cells pretreated with erythropoietin accelerate the repair of acute kidney injury
PMCID: Pubmed No.:33292452
Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents
PMCID: Pubmed No.:30972281
HDAC6/HNF4α loop mediated by miR-1 promotes bile acids-induced gastric intestinal metaplasia
PMCID: Pubmed No.:32705446
Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
PMCID: Pubmed No.:31694672
Porcine IGF-1R synonymous mutations in the intracellular domain affect cell proliferation and alter kinase activity
PMCID: Pubmed No.:32109480
The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation
PMCID: Pubmed No.:34112239
Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach
PMCID: Pubmed No.:34510400
Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I–MAVS Pathway and cGAS–STING Pathway
PMCID: Pubmed No.:33490069
A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells.
PMCID: Pubmed No.:34970539
Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine
PMCID: Pubmed No.:30825385
Luteolin ameliorates rat myocardial ischaemia–reperfusion injury through activation of peroxiredoxin II
PMCID: Pubmed No.:29782637
Pyrroloquinoline Quinone Prevents Estrogen Deficiency-Induced Osteoporosis by Inhibiting Oxidative Stress and Osteocyte Senescence
PMCID: Pubmed No.:30662347
Diastereoisomer-specific neurotoxicity of hexabromocyclododecane in human SH-SY5Y neuroblastoma cells
PMCID: Pubmed No.:31200309
PKCα mediated by the PI3K/Akt-FOXA1 cascade facilitates cypermethrin-induced hyperthyroidism
PMCID: Pubmed No.:33250241
Comparative Transcriptome Analysis Reveals the Protective Mechanism of Glycyrrhinic Acid for Deoxynivalenol-Induced Inflammation and Apoptosis in IPEC-J2 Cells
PMCID: Pubmed No.:33163144
Comparative Transcriptome Analysis Reveals the Protective Mechanism of Glycyrrhinic Acid for Deoxynivalenol-Induced Inflammation and Apoptosis in IPEC-J2 Cells
PMCID: Pubmed No.:33163144
MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation
PMCID: Pubmed No.:34853629
Theaflavin 3, 3-Digallate Delays Ovarian Aging by Improving Oocyte Quality and Regulating Granulosa Cell Function
PMCID: Pubmed No.:34925699
Luteolin Confers Cerebroprotection after Subarachnoid Hemorrhage by Suppression of NLPR3 Inflammasome Activation through Nrf2-Dependent Pathway
PMCID: Pubmed No.:34777689
Impaired Autophagy Induced by oxLDL/β2GPI/anti-β2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction
PMCID: Pubmed No.:34221236
Protective effects of rutin on liver injury in type 2 diabetic db/db mice
PMCID: Pubmed No.:30138894
Discovery of novel 3-hydroxyandrosta-5,7-Diene-17-Carboxylic acid derivatives as anti-inflammatory bowel diseases (IBD) agents
PMCID: Pubmed No.:33933753
YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis
PMCID: Pubmed No.:31028762
PIM1 kinase promotes cell proliferation, metastasis and tumor growth of lung adenocarcinoma by potentiating the c-MET signaling pathway
PMCID: Pubmed No.:30583073
Association between ARID2 and RAS-MAPK pathway in intellectual disability and short stature
PMCID: Pubmed No.:33051312
Period1 mediates rhythmic metabolism of toxins by interacting with CYP2E1
PMCID: Pubmed No.:33436540
Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner
PMCID: Pubmed No.:33473125
Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
PMCID: Pubmed No.:32001670
Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis
PMCID: Pubmed No.:32488049
The circadian clock gene Bmal1 facilitates cisplatin-induced renal injury and hepatization
PMCID: Pubmed No.:32522976
Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury
PMCID: Pubmed No.:30154436
Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma
PMCID: Pubmed No.:32792479
Melatonin alleviates hippocampal GR inhibition and depression-like behavior induced by constant light exposure in mice
PMCID: Pubmed No.:34794022
Heat stress affects fetal brain and intestinal function associated with the alterations of placental barrier in late pregnant mouse
PMCID: Pubmed No.:34695613
Effect of chlorogenic acid on alleviating inflammation and apoptosis of IPEC-J2 cells induced by deoxyniyalenol
PMCID: Pubmed No.:32961488
Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
PMCID: Pubmed No.:31768838
Nrf2 Down-Regulation by Camptothecin Favors Inhibiting Invasion, Metastasis and Angiogenesis in Hepatocellular Carcinoma
PMCID: Pubmed No.:34178646
Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2
PMCID: Pubmed No.:32004633
Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
PMCID: Pubmed No.:29935310
Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
PMCID: Pubmed No.:29935310
Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways
PMCID: Pubmed No.:29966698
Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II
PMCID: Pubmed No.:30502455
Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis
PMCID: Pubmed No.:33879841
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity
PMCID: Pubmed No.:31283229
Sirtuin 1 alleviates diabetic neuropathic pain by regulating synaptic plasticity of spinal dorsal horn neurons
PMCID: Pubmed No.:30649099
Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Antiaging and Antiosteoporosis Effects by Inactivating p16/p19 Signaling and Inhibiting Oxidative Stress
PMCID: Pubmed No.:30895687
Nrf2 antioxidant pathway suppresses Numb-mediated epithelial–mesenchymal transition during pulmonary fibrosis
PMCID: Pubmed No.:29362432
Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer
PMCID: Pubmed No.:30631043
Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation
PMCID: Pubmed No.:30166541
Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis
PMCID: Pubmed No.:30282980
LYW-6, a novel cryptotanshinone derived STAT3 targeting inhibitor, suppresses colorectal cancer growth and metastasis
PMCID: Pubmed No.:31982491
Food reward depends on TLR4 activation in dopaminergic neurons
PMCID: Pubmed No.:33971268
Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice
PMCID: Pubmed No.:32621955
Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/β‐Catenin in Primary Cilia of Osteoblasts
PMCID: Pubmed No.:30779853
Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways
PMCID: Pubmed No.:33628174
Piperazine-Derived α1D/1A Antagonist 1- Benzyl-N- (3-(4- (2-Methoxyphenyl) Piperazine-1-yl) Propyl) -1H- Indole-2- Carboxamide Induces Apoptosis in Benign Prostatic Hyperplasia Independently of α1-Adrenoceptor Blocking
PMCID: Pubmed No.:33584271
Neuroprotective Effects of Shenqi Fuzheng Injection in a Transgenic SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis
PMCID: Pubmed No.:34737697
Angelicin Alleviates Post-Trauma Osteoarthritis Progression by Regulating Macrophage Polarization via STAT3 Signaling Pathway
PMCID: Pubmed No.:34177582
PTEN Methylation Promotes Inflammation and Activation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
PMCID: Pubmed No.:34305608
Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway
PMCID: Pubmed No.:32754040
Actin polymerization state regulates osteogenic differentiation in human adipose-derived stem cells
PMCID: Pubmed No.:33858321
FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8 + T Cells During Ischemic Stroke
PMCID: Pubmed No.:32036560
Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice
PMCID: Pubmed No.:31978653
Oestrogen receptor α regulates the odonto/osteogenic differentiation of stem cells from apical papilla via ERK and JNK MAPK pathways
PMCID: Pubmed No.:30069950
Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats
PMCID: Pubmed No.:34413765
TBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination
PMCID: Pubmed No.:34663310
Novel Regulatory Roles of Wnt1 in Infection-Associated Colorectal Cancer
PMCID: Pubmed No.:29626750
Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway
PMCID: Pubmed No.:34922580
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease
PMCID: Pubmed No.:30157869
linc00968 inhibits the tumorigenesis and metastasis of lung adenocarcinoma via serving as a ceRNA against miR-9-5p and increasing CPEB3
PMCID: Pubmed No.:33159015
linc00968 inhibits the tumorigenesis and metastasis of lung adenocarcinoma via serving as a ceRNA against miR-9-5p and increasing CPEB3
PMCID: Pubmed No.:33159015
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice
PMCID: Pubmed No.:31048563
Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles
PMCID: Pubmed No.:31858836
SIRT1 Decreases Emotional Pain Vulnerability with Associated CaMKIIα Deacetylation in Central Amygdala
PMCID: Pubmed No.:32005763
PDK1 Regulates the Maintenance of Cell Body and the Development of Dendrites of Purkinje Cells by pS6 and PKCγ
PMCID: Pubmed No.:32487697
5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells aga
PMCID: Pubmed No.:30615919
Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway
PMCID: Pubmed No.:30691509
Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody–Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function
PMCID: Pubmed No.:32943546
Maggot excretions/secretions promote diabetic wound angiogenesis via miR18a/19a – TSP-1 axis
PMCID: Pubmed No.:32277954
Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3β Signaling Pathway In Vitro and In Vivo
PMCID: Pubmed No.:34463926
Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3β Signaling Pathway In Vitro and In Vivo
PMCID: Pubmed No.:34463926
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions
PMCID: Pubmed No.:32866756
IL‐1β/IL‐1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha‐synuclein pathology in the olfactory bulb, substantia nigra and striatum
PMCID: Pubmed No.:32678959
Membrane‐tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinoma
PMCID: Pubmed No.:30515785
White light emitting diode induces autophagy in hippocampal neuron cells through GSK-3-mediated GR and RORα pathways
PMCID: Pubmed No.:30923260
Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice
PMCID: Pubmed No.:30699097
Expression of a short antibody heavy chain peptide effectively antagonizes adenosine 2A receptor in vitro and in vivo
PMCID: Pubmed No.:32308059
Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway
PMCID: Pubmed No.:34281577
Piperine, as a TAS2R14 agonist, stimulates secretion of glucagon-like peptide-1 in human enteroendocrine cell line Caco-2
PMCID: Pubmed No.:34881772
Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice
PMCID: Pubmed No.:34128029
Crosstalk between soluble PDGF-BB and PDGFRβ promotes astrocytic activation and synaptic recovery in the hippocampus after subarachnoid hemorrhage
PMCID: Pubmed No.:31162947
JNK1 regulates RANKL-induced osteoclastogenesis via activation of a novel Bcl-2-Beclin1-autophagy pathway
PMCID: Pubmed No.:31295022
Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB–NFATc1 signal pathway
PMCID: Pubmed No.:30857415
Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation
PMCID: Pubmed No.:29401612
Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF-κB/p65
PMCID: Pubmed No.:33289070
Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress
PMCID: Pubmed No.:31790903
Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility
PMCID: Pubmed No.:31005715
The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-κB and CD9/gp130/STAT3 signalling pathway
PMCID: Pubmed No.:31837208
Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition
PMCID: Pubmed No.:34783554
trans 10, cis 12, but Not cis 9, trans 11 Conjugated Linoleic Acid Isomer Enhances Exercise Endurance by Increasing Oxidative Skeletal Muscle Fiber Type via Toll-like Receptor 4 Signaling in Mice
PMCID: Pubmed No.:34928153
trans 10, cis 12, but Not cis 9, trans 11 Conjugated Linoleic Acid Isomer Enhances Exercise Endurance by Increasing Oxidative Skeletal Muscle Fiber Type via Toll-like Receptor 4 Signaling in Mice
PMCID: Pubmed No.:34928153
Dietary Addition of Sodium Butyrate Contributes to Attenuated Feeding-Induced Hepatocyte Apoptosis in Dairy Goats
PMCID: Pubmed No.:30173520
Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens
PMCID: Pubmed No.:33422712
Pulsed Electromagnetic Fields Ameliorate Skeletal Deterioration in Bone Mass, Microarchitecture, and Strength by Enhancing Canonical Wnt Signaling-Mediated Bone Formation in Rats with Spinal Cord Injury
PMCID: Pubmed No.:33108939
Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy
PMCID: Pubmed No.:33855046
Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage
PMCID: Pubmed No.:33968980
Imperatorin inhibits mitogen-activated protein kinase and nuclear factor kappa-B signaling pathways and alleviates neuroinflammation in ischemic stroke
PMCID: Pubmed No.:34674376
Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury
PMCID: Pubmed No.:29581249
Effects of ALA-PDT on the Healing of Mouse Skin Wounds Infected With Pseudomonas aeruginosa and Its Related Mechanisms.
PMCID: Pubmed No.:33344449
USP18 deubiquitinates and stabilizes Twist1 to promote epithelial-mesenchymal transition in glioblastoma cells
PMCID: Pubmed No.:32368392
Targeting PI3K/Akt/Nrf2 pathway by glabridin alleviates acetaminophen-induced hepatic injury in rats
PMCID: Pubmed No.:33932887
Selenium nanoparticles fabricated in laminarin polysaccharides solutions exert their cytotoxicities in HepG2 cells by inhibiting autophagy and promoting apoptosis
PMCID: Pubmed No.:31284007
N16 suppresses RANKL-mediated osteoclatogenesis by down-regulating RANK expression
PMCID: Pubmed No.:31751723
Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia
PMCID: Pubmed No.:31290455
Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat
PMCID: Pubmed No.:31215503
Circular RNA SIPA1L1 regulates osteoblastic differentiation of stem cells from apical papilla via miR-204-5p/ALPL pathway
PMCID: Pubmed No.:33138854
Inhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species
PMCID: Pubmed No.:32190174
Astragalus membranaceus Injection Suppresses Production of Interleukin-6 by Activating Autophagy through the AMPK-mTOR Pathway in Lipopolysaccharide-Stimulated Macrophages
PMCID: Pubmed No.:32724488
SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes
PMCID: Pubmed No.:32733634
Activation of GPR55 attenuates cognitive impairment and neurotoxicity in a mouse model of Alzheimer's disease induced by Aβ1–42 through inhibiting RhoA/ROCK2 pathway
PMCID: Pubmed No.:34363866
A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling
PMCID: Pubmed No.:31645661
Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies
PMCID: Pubmed No.:32123298
Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation
PMCID: Pubmed No.:32341465
Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy
PMCID: Pubmed No.:32555442
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine
PMCID: Pubmed No.:32555444
Fluoxetine induces lipid metabolism abnormalities by acting on the liver in patients and mice with depression
PMCID: Pubmed No.:30150788
Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease
PMCID: Pubmed No.:29770796
Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway
PMCID: Pubmed No.:32855531
Effect of hyperglycemia on microglial polarization after cerebral ischemia-reperfusion injury in rats
PMCID: Pubmed No.:34052292
Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease
PMCID: Pubmed No.:32679144
1‐L‐MT, an IDO inhibitor, prevented colitis‐associated cancer by inducing CDC20 inhibition‐mediated mitotic death of colon cancer cells
PMCID: Pubmed No.:29607498
mTORC1 promotes mineralization via p53 pathway
PMCID: Pubmed No.:33508145
Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration
PMCID: Pubmed No.:31908035
Astaxanthin mitigates subarachnoid hemorrhage injury primarily by increasing sirtuin 1 and inhibiting the Toll‐like receptor 4 signaling pathway
PMCID: Pubmed No.:30048156
Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes
PMCID: Pubmed No.:32059841
Porcine milk exosome miRNAs protect intestinal epithelial cells against deoxynivalenol-induced damage
PMCID: Pubmed No.:32145262
Thiomyristoyl ameliorates colitis by blocking the differentiation of Th17 cells and inhibiting SIRT2-induced metabolic reprogramming
PMCID: Pubmed No.:33310666
Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene
PMCID: Pubmed No.:31699670
Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1–42 through Nrf2/HO-1 and NF-κB signaling pathway in mice
PMCID: Pubmed No.:34781121
JLX001 ameliorates cerebral ischemia injury by modulating microglial polarization and compromising NLRP3 inflammasome activation via the NF-κB signaling pathway
PMCID: Pubmed No.:34740080
5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis
PMCID: Pubmed No.:33536397
The RhoA/ROCK pathway mediates high glucose-induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways
PMCID: Pubmed No.:29745021
Serum- and glucocorticoid-inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1
PMCID: Pubmed No.:33724645
3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation
PMCID: Pubmed No.:29887940
DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide
PMCID: Pubmed No.:29805302
TIPRL, a Novel Tumor Suppressor, Suppresses Cell Migration, and Invasion Through Regulating AMPK/mTOR Signaling Pathway in Gastric Cancer
PMCID: Pubmed No.:32719745
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway
PMCID: Pubmed No.:29407955
The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling
PMCID: Pubmed No.:31884423
Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway
PMCID: Pubmed No.:32527985
Neuromedin B modulates phosphate-induced vascular calcification
PMCID: Pubmed No.:34674793
miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/β-catenin/ATF6 pathway in preadipocytes
PMCID: Pubmed No.:29483204
Hsa-let-7c controls the committed differentiation of IGF-1-treated mesenchymal stem cells derived from dental pulps by targeting IGF-1R via the MAPK pathways
PMCID: Pubmed No.:29650947
A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway
PMCID: Pubmed No.:31396207
A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis
PMCID: Pubmed No.:30425719
Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation
PMCID: Pubmed No.:32322162
MFG-E8 attenuates inflammation in subarachnoid hemorrhage by driving microglial M2 polarization
PMCID: Pubmed No.:33245889
FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
PMCID: Pubmed No.:30802446
Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats
PMCID: Pubmed No.:32084453
Protective effects of FGF10 on neurovascular unit in a rat model of neonatal hypoxic-ischemic brain injury
PMCID: Pubmed No.:32610105
Pretreatment with low-dose fimasartan ameliorates NLRP3 inflammasome-mediated neuroinflammation and brain injury after intracerebral hemorrhage
PMCID: Pubmed No.:30171865
Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage
PMCID: Pubmed No.:33727099
Decursinol angelate ameliorates 12-O-tetradecanoyl phorbol-13-acetate (TPA) -induced NF-κB activation on mice ears by inhibiting exaggerated inflammatory cell infiltration, oxidative stress and pro-inflammatory cytokine production
PMCID: Pubmed No.:31351099
Anthraquinone-type inhibitor of α-glucosidase enhances glucose uptake by activating an insulin-like signaling pathway in C2C12 myotubes
PMCID: Pubmed No.:31071387
Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway
PMCID: Pubmed No.:34521317
Chicoric Acid Improves Heart and Blood Responses to Hypobaric Hypoxia in Tibetan Yaks
PMCID: Pubmed No.:29433395
β‐arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury
PMCID: Pubmed No.:30793522
DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2‐Induced Hippocampal Neurogenesis in Mice Derived From Folic‐Acid‐Supplemented Dams
PMCID: Pubmed No.:30920123
Dysregulation of Krüppel-like factor 12 in the development of endometrial cancer
PMCID: Pubmed No.:30482501
Hypoxanthine Induces Muscular ATP Depletion and Fatigue via UCP2
PMCID: Pubmed No.:33746782
ERα and/or ERβ activation ameliorates cognitive impairment, neurogenesis and apoptosis in type 2 diabetes mellitus mice
PMCID: Pubmed No.:30201537
Protective effects of melatonin on sepsis-induced liver injury and dysregulation of gluconeogenesis in rats through activating SIRT1/STAT3 pathway
PMCID: Pubmed No.:31234024
Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia
PMCID: Pubmed No.:31972362
Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice
PMCID: Pubmed No.:29860219
FTO inhibits UPRmt-induced apoptosis by activating JAK2/STAT3 pathway and reducing m6A level in adipocytes
PMCID: Pubmed No.:34212271
Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway
PMCID: Pubmed No.:33685347
Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways
PMCID: Pubmed No.:31276209
Sodium fluoride regulates the osteo/odontogenic differentiation of stem cells from apical papilla by modulating autophagy
PMCID: Pubmed No.:30767218
AIM2 promotes non‐small‐cell lung cancer cell growth through inflammasome‐dependent pathway
PMCID: Pubmed No.:30953357
LncRNA AK077216 promotes RANKL‐induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45
PMCID: Pubmed No.:30132869
Long Noncoding RNA ANRIL Supports Proliferation of Adult T-Cell Leukemia Cells through Cooperation with EZH2
PMCID: Pubmed No.:30258009
Deficiency of the IRE1α-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1
PMCID: Pubmed No.:29263275
Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences
PMCID: Pubmed No.:33245480
Fucoxanthin Mitigates Subarachnoid Hemorrhage-Induced Oxidative Damage via Sirtuin 1-Dependent Pathway
PMCID: Pubmed No.:32876840
Inhibition of IRE1/JNK pathway in HK‐2 cells subjected to hypoxia‐reoxygenation attenuates mesangial cells‐derived extracellular matrix production
PMCID: Pubmed No.:33043579
NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β‐cells for protection
PMCID: Pubmed No.:33124187
Design and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury
PMCID: Pubmed No.:31491086
Role of mitochondrial calcium uniporter‐mediated Ca2+ and iron accumulation in traumatic brain injury
PMCID: Pubmed No.:30756474
Low levels of AMPK promote epithelial‐mesenchymal transition in lung cancer primarily through HDAC4‐ and HDAC5‐mediated metabolic reprogramming
PMCID: Pubmed No.:32519437
Role of CSE-Produced H2S on Cerebrovascular Relaxation via RhoA-ROCK Inhibition and Cerebral Ischemia-Reperfusion Injury in Mice
PMCID: Pubmed No.:30406996
Emodin prevents renal ischemia-reperfusion injury via suppression of CAMKII/DRP1-mediated mitochondrial fission
PMCID: Pubmed No.:34793771
Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models
PMCID: Pubmed No.:34861210
A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway
PMCID: Pubmed No.:30153443
Iso-suillin-induced DNA damage leading to cell cycle arrest and apoptosis arised from p53 phosphorylation in A549 cells
PMCID: Pubmed No.:34217708
Erythropoietin alleviates hepatic steatosis by activating SIRT1-mediated autophagy
PMCID: Pubmed No.:29522896
Integrating bioinformatics with pharmacological evaluation for illustrating the action mechanism of herbal formula Jiao'e mixture in suppressing lung carcinoma
PMCID: Pubmed No.:34400263
Ginseng root extract attenuates inflammation by inhibiting the MAPK/NF-κB signaling pathway and activating autophagy and p62-Nrf2-Keap1 signaling in vitro and in vivo
PMCID: Pubmed No.:34648903
Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice
PMCID: Pubmed No.:30144494
Silymarin ameliorates the disordered glucose metabolism of mice with diet-induced obesity by activating the hepatic SIRT1 pathway
PMCID: Pubmed No.:33901577
Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS
PMCID: Pubmed No.:32343612
The expression of diacylglycerol kinase isoforms α and ζ correlates with the progression of experimental autoimmune encephalomyelitis in rats
PMCID: Pubmed No.:34312706
Selective Antagonism of Bcl-xL Potentiates M1 Oncolysis by Enhancing Mitochondrial Apoptosis
PMCID: Pubmed No.:28750564
Atractylenolide III ameliorates cerebral ischemic injury and neuroinflammation associated with inhibiting JAK2/STAT3/Drp1-dependent mitochondrial fission in microglia
PMCID: Pubmed No.:30981186
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation
PMCID: Pubmed No.:30700991
LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation
PMCID: Pubmed No.:32936696
Resveratrol chemosensitizes adriamycin‐resistant breast cancer cells by modulating miR‐122‐5p
PMCID: Pubmed No.:31155753
The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients
PMCID: Pubmed No.:31034651
Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS
PMCID: Pubmed No.:34758863
The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer
PMCID: Pubmed No.:32958014
Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase
PMCID: Pubmed No.:31798444
MicroRNA-141-5p Acts as a Tumor Suppressor via Targeting RAB32 in Chronic Myeloid Leukemia
PMCID: Pubmed No.:32038235
YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
PMCID: Pubmed No.:31031629
Effects of D-Chiro-Inositol on Glucose Metabolism in db/db Mice and the Associated Underlying Mechanisms
PMCID: Pubmed No.:32273844
Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling
PMCID: Pubmed No.:32848779
Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses
PMCID: Pubmed No.:34755645
Albumin fusion improves the pharmacokinetics and in vivo antitumor efficacy of canine interferon gamma
PMCID: Pubmed No.:30639219
Artemisinin Derivatives Inhibit Non-small Cell Lung Cancer Cells Through Induction of ROS-dependent Apoptosis/Ferroptosis
PMCID: Pubmed No.:34093811
Extracellular Glutamate-Induced mTORC1 Activation via the IR/IRS/PI3K/Akt Pathway Enhances the Expansion of Porcine Intestinal Stem Cells
PMCID: Pubmed No.:31382738
Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities
PMCID: Pubmed No.:33284020
Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis
PMCID: Pubmed No.:30040410
Long-Term High-Fat Diet Decreases Hepatic Iron Storage Associated with Suppressing TFR2 and ZIP14 Expression in Rats
PMCID: Pubmed No.:30350980
A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma
PMCID: Pubmed No.:29321718
Amelioration of non-alcoholic fatty liver disease by sodium butyrate is linked to the modulation of intestinal tight junctions in db/db mice
PMCID: Pubmed No.:33216087
The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model
PMCID: Pubmed No.:34951679
Heat exposure impairs porcine oocyte quality with suppressed actin expression in cumulus cells and disrupted F-actin formation in transzonal projections
PMCID: Pubmed No.:32647569
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury
PMCID: Pubmed No.:34403762
Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway
PMCID: Pubmed No.:33688167
Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression
PMCID: Pubmed No.:34462883
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma
PMCID: Pubmed No.:31824170
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1
PMCID: Pubmed No.:34897970
Pro‑atherogenic activation of A7r5 cells induced by the oxLDL/β2GPI/anti‑β2GPI complex
PMCID: Pubmed No.:30085340
The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study
PMCID: Pubmed No.:29661186
Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro
PMCID: Pubmed No.:32458347
Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation
PMCID: Pubmed No.:32115816
Sarsasapogenin ameliorates diabetes‐associated memory impairment and neuroinflammation through down‐regulation of PAR‐1 receptor
PMCID: Pubmed No.:33885189
Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats
PMCID: Pubmed No.:29682805
Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice
PMCID: Pubmed No.:30699879
WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation
PMCID: Pubmed No.:32868491
A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway
PMCID: Pubmed No.:31132419
Isoflurane anesthesia in aged mice and effects of A1 adenosine receptors on cognitive impairment
PMCID: Pubmed No.:29345054
Inhibition of Autophagy with Chloroquine Enhanced Sinoporphyrin Sodium Mediated Photodynamic Therapy-induced Apoptosis in Human Colorectal Cancer Cells
PMCID: Pubmed No.:30662343
Interleukin-27 prevents LPS-induced inflammatory osteolysis by inhibiting osteoclast formation and function
PMCID: Pubmed No.:30972153
P27 deletion enhances hematopoiesis by paracrine action of IL22 secreted from bone marrow mesenchymal stem cells
PMCID: Pubmed No.:32269712
Chemokine receptor 7 overexpression promotes mesenchymal stem cell migration and proliferation via secreting Chemokine ligand 12
PMCID: Pubmed No.:29317710
Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy
PMCID: Pubmed No.:31235817
Inhibitory effects of isocryptotanshinone on gastric cancer
PMCID: Pubmed No.:29915371
A multifunctional DNA nano-scorpion for highly efficient targeted delivery of mRNA therapeutics
PMCID: Pubmed No.:29976947
Attenuation of melanogenesis by Nymphaea nouchali (Burm. f) flower extract through the regulation of cAMP/CREB/MAPKs/MITF and proteasomal degradation of tyrosinase
PMCID: Pubmed No.:30224716
Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
PMCID: Pubmed No.:34170454
DR7 encoded by human herpesvirus 6 promotes glioma development and progression
PMCID: Pubmed No.:30881135
Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex
PMCID: Pubmed No.:33080316
The biphasic effects of the oxLDL/β2GPI/anti-β2GPI complex on VSMC proliferation and apoptosis
PMCID: Pubmed No.:30738928
BMP9 inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via the PI3K/AKT signaling pathway
PMCID: Pubmed No.:31203157
MCTR3 reduces LPS-induced acute lung injury in mice via the ALX/PINK1 signaling pathway
PMCID: Pubmed No.:33268042
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation
PMCID: Pubmed No.:31926446
Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice
PMCID: Pubmed No.:32087497
Effects of interleukin-6 and IL-6/AMPK signaling pathway on mitochondrial biogenesis and astrocytes viability under experimental septic condition
PMCID: Pubmed No.:29674256
Neuroprotective effects of novel compound Tozan on cognition, neurogenesis and apoptosis in diabetes
PMCID: Pubmed No.:34734023
Syngeneic bone marrow transplantation in combination with PI3K inhibitor reversed hyperglycemia in later-stage streptozotocin-induced diabetes
PMCID: Pubmed No.:34988151
Impairment of Intestinal Monocarboxylate Transporter 6 Function and Expression in Diabetic Rats Induced by Combination of High-Fat Diet and Low Dose of Streptozocin: Involvement of Butyrate–Peroxisome Proliferator-Activated Receptor-γ Activation
PMCID: Pubmed No.:30923035
Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters
PMCID: Pubmed No.:31399507
ClC-3 chloride channel protein induces G1 arrest in hepatocellular carcinoma Hep3B cells
PMCID: Pubmed No.:29749557
The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells
PMCID: Pubmed No.:31281369
Polydatin protects SH-SY5Y in models of Parkinson's disease by promoting Atg5-mediated but parkin-independent autophagy
PMCID: Pubmed No.:31926197
Curcumin-activated autophagy plays a negative role in its anti-osteoclastogenic effect
PMCID: Pubmed No.:31678610
Paternal systemic inflammation induces offspring programming of growth and liver regeneration in association with Igf2 upregulation
PMCID: Pubmed No.:32882328
PSTPIP2 Inhibits the Inflammatory Response and Proliferation of Fibroblast-Like Synoviocytes in vitro
PMCID: Pubmed No.:30564127
MiR-27a-3p enhances the cisplatin sensitivity in hepatocellular carcinoma cells through inhibiting PI3K/Akt pathway
PMCID: Pubmed No.:34096570
Identification of extracellular vesicles-transported miRNAs in Erlotinib-resistant head and neck squamous cell carcinoma
PMCID: Pubmed No.:32157550
Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice
PMCID: Pubmed No.:31452288
hucMSCs Attenuate IBD through Releasing miR148b-5p to Inhibit the Expression of 15-lox-1 in Macrophages
PMCID: Pubmed No.:31275059
A Novel Putative Role of TNK1 in Atherosclerotic Inflammation Implicating the Tyk2/STAT1 Pathway
PMCID: Pubmed No.:32694928
Both LmCYP4G genes function in decreasing cuticular penetration of insecticides in Locusta migratoria
PMCID: Pubmed No.:32419293
C-peptide ameliorates high glucose-induced podocyte dysfunction through the regulation of the Notch and TGF-β signaling pathways
PMCID: Pubmed No.:33901627
Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma
PMCID: Pubmed No.:30021341
CXCR1/CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy
PMCID: Pubmed No.:30257327
Norfloxacin suppresses Leptospira-induced inflammation through inhibiting p65 and ERK phosphorylation and NLRP3 inflammasome activation
PMCID: Pubmed No.:34826552
The novel GLP-1/GIP dual agonist DA3-CH is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury
PMCID: Pubmed No.:33500109
Essential oil from Fructus Alpinia zerumbet (fruit of Alpinia zerumbet (Pers.) Burtt.et Smith) protected against aortic endothelial cell injury and inflammation in vitro and in vivo
PMCID: Pubmed No.:30880260
Effects of Agriophyllum squarrosum extracts on glucose metabolism in KKAy mice and the associated underlying mechanisms
PMCID: Pubmed No.:31158442
Phenylethanoid glycosides of Callicarpa kwangtungensis Chun exert cardioprotective effect by weakening Na+-K+-ATPase/Src/ERK1/2 pathway and inhibiting apoptosis mediated by oxidative stress and inflammation
PMCID: Pubmed No.:32311484
Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury
PMCID: Pubmed No.:32946961
Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice
PMCID: Pubmed No.:30096284
A balanced game: chicken macrophage response to ALV-J infection
PMCID: Pubmed No.:30841905
Dexmedetomidine Attenuates Neuroinflammatory–Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway
PMCID: Pubmed No.:31478596
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy
PMCID: Pubmed No.:30686973
Carbon ion combined with tigecycline inhibits lung cancer cell proliferation by inducing mitochondrial dysfunction
PMCID: Pubmed No.:33065148
PGRN−/− TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration
PMCID: Pubmed No.:33181174
Effects of low-dose ALA-PDT on fibroblast photoaging induced by UVA irradiation and the underlying mechanisms
PMCID: Pubmed No.:31075320
HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator
PMCID: Pubmed No.:31022492
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
PMCID: Pubmed No.:29609003
Upregulation of α enolase (ENO1) crotonylation in colorectal cancer and its promoting effect on cancer cell metastasis
PMCID: Pubmed No.:34547627
CTRP9 induces iNOS expression through JAK2/STAT3 pathway in Raw 264.7 and peritoneal macrophages
PMCID: Pubmed No.:31837806
METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels
PMCID: Pubmed No.:33740664
Role and mechanism of miR-4778-3p and its targets NR2C2 and Med19 in cervical cancer radioresistance
PMCID: Pubmed No.:30473219
Bmi-1 determines the stemness of renal stem or progenitor cells
PMCID: Pubmed No.:32819581
Porcine Milk Exosome MiRNAs Attenuate LPS-Induced Apoptosis through Inhibiting TLR4/NF-κB and p53 Pathways in Intestinal Epithelial Cells
PMCID: Pubmed No.:31429552
Paclitaxel‑resistant gastric cancer MGC‑803 cells promote epithelial‑to‑mesenchymal transition and chemoresistance in paclitaxel‑sensitive cells via exosomal delivery of miR‑155‑5p
PMCID: Pubmed No.:30365045
Shp2 regulates PM2.5-induced airway epithelial barrier dysfunction by modulating ERK1/2 signaling pathway
PMCID: Pubmed No.:34252507
MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells
PMCID: Pubmed No.:33033519
Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4
PMCID: Pubmed No.:31618077
Yap regulates mitochondrial structural remodeling during myoblast differentiation
PMCID: Pubmed No.:29898377
Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity
PMCID: Pubmed No.:30321647
Tert-butylhydroquinone enhanced angiogenesis and astrocyte activation by activating nuclear factor-E2-related factor 2/heme oxygenase-1 after focal cerebral ischemia in mice
PMCID: Pubmed No.:31283926
Small intestine proteomics coupled with serum metabolomics reveal disruption of amino acid metabolism in Chinese hamsters with type 2 diabetes mellitus
PMCID: Pubmed No.:32428569
Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway
PMCID: Pubmed No.:30690062
Absent in melanoma 2 suppresses epithelial‐mesenchymal transition via Akt and inflammasome pathways in human colorectal cancer cells
PMCID: Pubmed No.:31210372
miR‐125a‐3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11
PMCID: Pubmed No.:31489990
Luteolin attenuates high glucose-induced podocyte injury via suppressing NLRP3 inflammasome pathway
PMCID: Pubmed No.:30935950
Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway
PMCID: Pubmed No.:31042302
Astrocyte elevated gene‐1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4
PMCID: Pubmed No.:30520133
Dietary betaine activates hepatic VTGII expression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression
PMCID: Pubmed No.:29375826
Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in female piglets fed Fusarium mycotoxins contaminated diet
PMCID: Pubmed No.:30805184
MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin
PMCID: Pubmed No.:30181714
Ezrin interacts with L-periaxin by the “head to head and tail to tail” mode and influences the location of L-periaxin in Schwann cell RSC96
PMCID: Pubmed No.:31931020
Tprn is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice
PMCID: Pubmed No.:30159668
YAP mediates the interaction between the Hippo and PI3K/Akt pathways in mesangial cell proliferation in diabetic nephropathy
PMCID: Pubmed No.:32816106
miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4
PMCID: Pubmed No.:29484417
Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1
PMCID: Pubmed No.:29917167
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes
PMCID: Pubmed No.:31639486
Autophagy mediated by JNK1 resists apoptosis through TRAF3 degradation in osteoclastogenesis
PMCID: Pubmed No.:31654668
Insulin exacerbated high glucose-induced epithelial-mesenchymal transition in prostatic epithelial cells BPH-1 and prostate cancer cells PC-3 via MEK/ERK signaling pathway
PMCID: Pubmed No.:32561286
Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264.7 cells
PMCID: Pubmed No.:29423011
N-acetylcysteine prevents orchiectomy-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence
PMCID: Pubmed No.:31396339
Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury
PMCID: Pubmed No.:30787978
Pyrroloquinoline quinone prevents knee osteoarthritis by inhibiting oxidative stress and chondrocyte senescence
PMCID: Pubmed No.:30972174
Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence
PMCID: Pubmed No.:32194914
Mitochondrial-targeted antioxidant MitoQ provides neuroprotection and reduces neuronal apoptosis in experimental traumatic brain injury possibly via the Nrf2-ARE pathway
PMCID: Pubmed No.:30018728
Sodium aescinate provides neuroprotection in experimental traumatic brain injury via the Nrf2-ARE pathway
PMCID: Pubmed No.:32014567
Deletion of aquaporin-4 aggravates brain pathology after blocking of the meningeal lymphatic drainage
PMCID: Pubmed No.:30347264
Diet containing stearic acid increases food reward-related behaviors in mice compared with oleic acid
PMCID: Pubmed No.:32822805
Delayed metformin treatment improves functional recovery following traumatic brain injury via central AMPK-dependent brain tissue repair
PMCID: Pubmed No.:32858129
Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathway
PMCID: Pubmed No.:29626606
Post-exercise Effects and Long-Term Training Adaptations of Hormone Sensitive Lipase Lipolysis Induced by High-Intensity Interval Training in Adipose Tissue of Mice.
PMCID: Pubmed No.:33324231
Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner
PMCID: Pubmed No.:31437794
Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms
PMCID: Pubmed No.:31473406
Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice
PMCID: Pubmed No.:30986644
Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell
PMCID: Pubmed No.:31005778
Effect of silencing HIF-1α gene on testicle spermatogenesis function in varicocele rats
PMCID: Pubmed No.:31377879
Combination therapy with F5/35 fiber chimeric conditionally replicative adenoviruses expressing IL‐24 enhances the antitumor effect of temozolomide against melanoma
PMCID: Pubmed No.:30406970
The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
PMCID: Pubmed No.:32811532
Chitosan-gold nanoparticles mediated gene delivery of c-myb facilitates osseointegration of dental implants in ovariectomized rat
PMCID: Pubmed No.:30307328
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.