Contact us : info@bioworlde.com
Home > Product > Primary Antibodies
Bax (C62) polyclonal antibody BS2538
  • Western blot (WB) analysis of Bax (S4) polyclonal antibody at 1:500 dilution LaneA:The Brain cord tissue lysate of Mouse(40ug) LaneB:The Brain tissue lysate of Rat(40ug) LaneC:A2780 whole cell lysate(40ug) LaneD:MCF-7 whole cell lysate(40ug)
  • Immunofluorescence analysis of A549 cells using Bax (C62) pAb at dilution of 1:50.
  • Immunofluorescence analysis of A549 cells using Bax (C62) pAb at dilution of 1:50.
Product NameBax (C62) polyclonal antibody
Catalog No.BS2538
Swiss-ProtQ07812
Host Rabbit
ReactivityHuman,Mouse,Rat
ApplicationsWB IHC IF
Application_allWB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
BiowMW~ 21 kDa
Alternative NameApoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4
Purification&PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
ConjugateUnconjugated
ModificationUnmodification
Browse similar products>>
Size Price
50ul $158
100ul $275
Add to cart My orders
Product Name :
Bax (C62) polyclonal antibody
Background :
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :
Bax (C62) polyclonal antibody detects endogenous levels of Bax protein.
Immunogen :
Synthetic peptide, corresponding to Human Bax.
Conjugate :
Unconjugated
Modification :
Unmodification
  • Western blot (WB) analysis of Bax (S4) polyclonal antibody at 1:500 dilution LaneA:The Brain cord tissue lysate of Mouse(40ug) LaneB:The Brain tissue lysate of Rat(40ug) LaneC:A2780 whole cell lysate(40ug) LaneD:MCF-7 whole cell lysate(40ug)
  • Immunofluorescence analysis of A549 cells using Bax (C62) pAb at dilution of 1:50.
  • Immunofluorescence analysis of A549 cells using Bax (C62) pAb at dilution of 1:50.
The Long Intergenic Noncoding RNA UFC1, a Target of MicroRNA 34a, Interacts With the mRNA Stabilizing Protein HuR to Increase Levels of β-Catenin in HCC Cells PMCID:    Pubmed No.:25449213 Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells PMCID:    Pubmed No.:27463126 Involvement of JNK and P53 Activation in G2/M Cell Cycle Arrest and Apoptosis induced by Titanium Dioxide Nanoparticles in neuron cells PMCID:    Pubmed No.:20863874 Small interfering RNA targeting integrin-linked kinase inhibited the growth and induced apoptosis in human bladder cancer cells PMCID:    Pubmed No.:21601006 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways PMCID:    Pubmed No.:21901545 Inhibition of activated Stat3 reverses drug resistance to chemotherapeutic agents in gastric cancer cells PMCID:    Pubmed No.:22104727 (S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death PMCID:    Pubmed No.:22142531 Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy PMCID:    Pubmed No.:22248367 A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice PMCID:    Pubmed No.:22458555 Microcystin-LR Induces Ceramide to Regulate PP2A and Destabilize Cytoskeleton in HEK293 Cells PMCID:    Pubmed No.:22523228 Down regulation of differentiated embryonic chondrocytes 1 (DEC1) is involved in 8-methoxypsoralen-induced apoptosis in HepG2 cells PMCID:    Pubmed No.:22796345 Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through fas- and mitochondria-mediated pathways† PMCID:    Pubmed No.:22821714 Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: Involvement of Akt/NF-κB pathway PMCID:    Pubmed No.:22963993 Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus PMCID:    Pubmed No.:22995439 Phycocyanin may suppress d-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways PMCID:    Pubmed No.:23036742 Paclitaxel-Fe3O4 nanoparticles inhibit growth of CD138- CD34- tumor stem-like cells in multiple myeloma-bearing mice PMCID:    Pubmed No.:23610522 Effect of bone marrow mesenchymal stem cells from blastic phase chronic myelogenous leukemia on the growth and apoptosis of leukemia cells PMCID:    Pubmed No.:23733230 Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury PMCID:    Pubmed No.:None Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury PMCID:    Pubmed No.:24335166 Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells PMCID:    Pubmed No.:24484372 Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats PMCID:    Pubmed No.:24613208 Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway. PMCID:    Pubmed No.:24769129 Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways PMCID:    Pubmed No.:25270871 Huangzhi Oral Liquid Prevents Arrhythmias by Upregulating Caspase-3 and Apoptosis Network Proteins in Myocardial Ischemia-Reperfusion Injury in Rats PMCID:    Pubmed No.:26074995 LW‐213 induces G2/M cell cycle arrest through AKT/GSK3β/β‐catenin signaling pathway in human breast cancer cells PMCID:    Pubmed No.:25945460 8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition PMCID:    Pubmed No.:26316083 Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO 2-induced senescent mice PMCID:    Pubmed No.:27064004 PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis in leukemia cells PMCID:    Pubmed No.:26860588 Effects of gastrokine‑2 expression on gastric cancer cell apoptosis by activation of extrinsic apoptotic pathways PMCID:    Pubmed No.:25270871 Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury PMCID:    Pubmed No.:None Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO 2-induced senescent mice PMCID:    Pubmed No.:27064004 PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis in leukemia cells PMCID:    Pubmed No.:26860588 Ribonuclease inhibitor up-regulation inhibits the growth and induces apoptosis in murine melanoma cells through repression of angiogenin and ILK/PI3K/AKT signaling pathway. PMCID:    Pubmed No.:24769129 Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury PMCID:    Pubmed No.:24335166 Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells PMCID:    Pubmed No.:24484372 Norisoboldine induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats PMCID:    Pubmed No.:24613208 Racemic oleracein E increases the survival rate and attenuates memory impairment in D-galactose/NaNO2-induced senescent mice PMCID:    Pubmed No.:27064004 Phenolic alkaloid oleracein E attenuates oxidative stress and neurotoxicity in AlCl3-treated mice PMCID:    Pubmed No.:29054451 Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling PMCID:    Pubmed No.:26177745 LW‐213 induces G2/M cell cycle arrest through AKT/GSK3β/β‐catenin signaling pathway in human breast cancer cells PMCID:    Pubmed No.:25945460 Celastrol suppresses the proliferation of lung adenocarcinoma cells by regulating microRNA-24 and microRNA-181b PMCID:    Pubmed No.:29434967 Downregulation of Foxc2 enhances apoptosis induced by 5-fluorouracil through activation of MAPK and AKT pathways in colorectal cancer PMCID:    Pubmed No.:26893778 Saponin 6 derived from Anemone taipaiensis induces U87 human malignant glioblastoma cell apoptosis via regulation of Fas and Bcl‑2 family proteins PMCID:    Pubmed No.:27175997 Imiquimod inhibits the growth of SGC‑7901 cells in vitro through induction of autophagy and apoptosis PMCID:    Pubmed No.:26549648 Rhus javanica Linn protects against hydrogen peroxide‑induced toxicity in human Chang liver cells via attenuation of oxidative stress and apoptosis signaling PMCID:    Pubmed No.:26648020 Huangzhi Oral Liquid Prevents Arrhythmias by Upregulating Caspase-3 and Apoptosis Network Proteins in Myocardial Ischemia-Reperfusion Injury in Rats PMCID:    Pubmed No.:26074995 Association between integrin‑linked kinase and hyperthermia in oral squamous cell carcinoma PMCID:    Pubmed No.:29250172 Effect of vascular endothelial growth factor siRNA and wild‑type p53 co‑expressing plasmid in MDA‑MB‑231 cells PMCID:    Pubmed No.:26573068 Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells PMCID:    Pubmed No.:28849123 C1 inhibitor‑mediated myocardial protection from chronic intermittent hypoxia‑induced injury PMCID:    Pubmed No.:27698713 RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells PMCID:    Pubmed No.:26063610 Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury PMCID:    Pubmed No.:30237401 Potent effects of dioscin against hepatocellular carcinoma through regulating TP53‐induced glycolysis and apoptosis regulator (TIGAR)‐mediated apoptosis, autophagy, and DNA damage PMCID:    Pubmed No.:30710454 A Protein from Dioscorea polystachya (Chinese Yam) Improves Hydrocortisone-Induced Testicular Dysfunction by Alleviating Leydig Cell Injury via Upregulation of the Nrf2 Pathway PMCID:    Pubmed No.:34887997 The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice PMCID:    Pubmed No.:34777697 Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo PMCID:    Pubmed No.:30551497 Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice PMCID:    Pubmed No.:34084135 Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome PMCID:    Pubmed No.:30633969 Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways PMCID:    Pubmed No.:32573644 A novel drug-free strategy of nano-pulse stimulation sequence (NPSS) in oral cancer therapy: In vitro and in vivo study PMCID:    Pubmed No.:29719274 Reversal Effects of Bound Polyphenol from Foxtail Millet Bran on Multidrug Resistance in Human HCT-8/Fu Colorectal Cancer Cell PMCID:    Pubmed No.:29730933 Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells PMCID:    Pubmed No.:33663206 Targeting PI3K/Akt/Nrf2 pathway by glabridin alleviates acetaminophen-induced hepatic injury in rats PMCID:    Pubmed No.:33932887 The RhoA/ROCK pathway mediates high glucose-induced cardiomyocyte apoptosis via oxidative stress, JNK, and p38MAPK pathways PMCID:    Pubmed No.:29745021 Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway PMCID:    Pubmed No.:31523192 The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling PMCID:    Pubmed No.:31884423 HucMSC exosome-delivered 14-3-3ζ alleviates ultraviolet radiation-induced photodamage via SIRT1 pathway modulation PMCID:    Pubmed No.:33882455 Toosendanin Shows Potent Efficacy Against Human Ovarian Cancer through Caspase-Dependent Mitochondrial Apoptotic Pathway PMCID:    Pubmed No.:34521317 Mineralocorticoid receptor deficiency improves the therapeutic effects of mesenchymal stem cells for myocardial infarction via enhanced cell survival PMCID:    Pubmed No.:30549184 A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway PMCID:    Pubmed No.:30153443 The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway PMCID:    Pubmed No.:34425100 Long noncoding RNA DINO (damage induced noncoding) represses the development of gastric cancer by modulating p21 and Bcl-2 Associated X Protein (Bax) expression PMCID:    Pubmed No.:30775800 Long noncoding RNA LINC00961 inhibits cell proliferation and induces cell apoptosis in human non–small cell lung cancer PMCID:    Pubmed No.:30010215 Diterpene Ginkgolides Meglumine Injection inhibits apoptosis induced by optic nerve crush injury via modulating MAPKs signaling pathways in retinal ganglion cells PMCID:    Pubmed No.:34181957 Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling PMCID:    Pubmed No.:32848779 Protective effects of Salidroside on cardiac function in mice with myocardial infarction PMCID:    Pubmed No.:31792327 Profiles of messenger RNAs and MicroRNAs in hypoxia-induced hepatic stellate cells PMCID:    Pubmed No.:34734003 LncRNA-GAS5 promotes spinal cord repair and the inhibition of neuronal apoptosis via the transplantation of 3D printed scaffold loaded with induced pluripotent stem cell-derived neural stem cells PMCID:    Pubmed No.:34350246 Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc PMCID:    Pubmed No.:30186330 The novel GLP-1/GIP dual agonist DA3-CH is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury PMCID:    Pubmed No.:33500109 Ursolic acid induces apoptosis and anoikis in colorectal carcinoma RKO cells PMCID:    Pubmed No.:33549076 LncRNA SNHG6 Inhibits Apoptosis by Regulating EZH2 Expression via the Sponging of MiR-101-3p in Esophageal Squamous-Cell Carcinoma PMCID:    Pubmed No.:33192074 Echinocystic acid provides a neuroprotective effect via the PI3K/AKT pathway in intracerebral haemorrhage mice PMCID:    Pubmed No.:32055597 Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model PMCID:    Pubmed No.:33433498 Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling PMCID:    Pubmed No.:30323140 Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinoma PMCID:    Pubmed No.:34159092 Rosiglitazone attenuates cell apoptosis through antioxidative and anti-apoptotic pathways in the hippocampi of spontaneously hypertensive rats PMCID:    Pubmed No.:30483729 Induction of microRNA‑let‑7a inhibits lung adenocarcinoma cell growth by regulating cyclin D1 PMCID:    Pubmed No.:30066899 Adipokine zinc-α2-glycoprotein alleviates lipopolysaccharide-induced inflammatory responses through the β3-AR/PKA/CREB pathway PMCID:    Pubmed No.:31260855 Mitochondrial targeting of TR3 is involved in TPA induced apoptosis in breast cancer cells PMCID:    Pubmed No.:30641217 Anticancer roles of let‑7f‑1‑3p in non‑small cell lung cancer via direct targeting of integrin β1 PMCID:    Pubmed No.:34630660 Effect of Heat Treatment on the Anticancer Activity of Houttuynia cordata Thunb Aerial Stem Extract in Human Gastric Cancer SGC-7901 Cells PMCID:    Pubmed No.:32180441 -Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-B Signaling in Colon Cancer Cells PMCID:    Pubmed No.:30363706 The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model PMCID:    Pubmed No.:31121474 Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus PMCID:    Pubmed No.:29549796 IFN‑γ induces apoptosis in human melanocytes by activating the JAK1/STAT1 signaling pathway PMCID:    Pubmed No.:32945463 Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis PMCID:    Pubmed No.:33222922 Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells PMCID:    Pubmed No.:32424110 Ethanol Extract of Hizikia fusiforme Induces Apoptosis in B16F10 Mouse Melanoma Cells through ROS-Dependent Inhibition of the PI3K/Akt Signaling Pathway PMCID:    Pubmed No.:32458633 Quercetin protects human liver cells from o,p’-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production PMCID:    Pubmed No.:35122929 Delivery of miR-3529-3p using MnO2-SiO2-APTES nanoparticles combined with phototherapy suppresses lung adenocarcinoma progression by targeting HIGD1A PMCID:    Pubmed No.:36808485 Radiosensitization of Nasopharyngeal Carcinoma by Graphene Oxide Nanosheets to Reduce Bcl-2 Level PMCID:    Pubmed No.:36913208 QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation PMCID:    Pubmed No.:37496671 Pioglitazone protects PC12 cells against oxidative stress injury: An in vitro study of its antiapoptotic effects via the PPARγ pathway PMCID:    Pubmed No.:37854503
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

Price/Size :

USD 368/1mg/vial



Tips: 

For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).

Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 


Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.
COPYRIGHT © 2015-2018 Bioworld Technology, Inc. All rights reserved POLYCLONAL AND MONOCLONAL ANTIBODY CENTER