Product Name :
MMP-2 (L638) polyclonal antibody Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MMP-2 (L638) polyclonal antibody detects endogenous levels of MMP-2 protein. Immunogen :
Synthetic peptide, corresponding to Human MMP-2. Conjugate :
Unconjugated Modification :
Unmodification
MMP-2 (L638) polyclonal antibody Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MMP-2 (L638) polyclonal antibody detects endogenous levels of MMP-2 protein. Immunogen :
Synthetic peptide, corresponding to Human MMP-2. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of MMP-2 (L638) polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:HuT78 whole cell lysate LaneC:H1792 whole cell lysate LaneD:The Brain tissue lysate of Mouse(40ug) LaneE:The Lung tissue lysate of Mouse(40ug) LaneF:The Brain tissue lysate of Rat(40ug) LaneG:The Lung tissue lysate of Rat(40ug)
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Immunofluorescence analysis of Hela cells using MMP-2 antibody at dilution of 1:50.
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Immunofluorescence analysis of Hela cells using MMP-2 antibody at dilution of 1:50.
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LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells
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Methylation of TFPI-2 is an early event of esophageal carcinogenesis
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Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells
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Natural Products as a Gold Mine for Selective Matrix Metalloproteinases Inhibitors
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Effect of Etiasa on the expression of matrix metalloproteinase-2 and tumor necrosis factor-α in a rat model of ulcerative colitis.
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Effects of DEHP on endometrial receptivity and embryo implantation in pregnant mice
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Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats
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The Antioxidant Property of Pachymic Acid Improves Bone Disturbance against AH Plus–induced Inflammation in MC-3T3 E1 Cells
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Induction of Thoracic Aortic Remodeling by Endothelial-Specific Deletion of MicroRNA-21 in Mice
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Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy
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A novel role of ribonuclease inhibitor in regulation of epithelial-to-mesenchymal transition and ILK signaling pathway in bladder cancer cells
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Small interfering RNA targeting ILK inhibits metastasis in human tongue cancer cells through repression of epithelial-to-mesenchymal transition
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Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model.
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CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.
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HDAC10 suppresses cervical cancer metastasis through inhibition of matrix metalloproteinase (MMP) 2 and 9 expression
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Epigenetic Silencing of CXCL14 Induced Colorectal Cancer Migration and Invasion
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MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4
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Abnormal expression of CDK11p58 in prostate cancer
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IDH1 Overexpression Induced Chemotherapy Resistance and IDH1 Mutation Enhanced Chemotherapy Sensitivity in Glioma Cells in Vitro and in Vivo
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Inhibition of metastatic tumor growth and metastasis via targeting metastatic breast cancer by chlorotoxin-modified liposomes
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Icaritin suppresses the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression
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Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway
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Activation of glucagon‐like peptide‐1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway
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Granulocyte/Macrophage Colony-Stimulating Factor Influences Angiogenesis by Regulating the Coordinated Expression of VEGF and the Ang/Tie System
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Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
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Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway
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Poloxamer-188 Can Attenuate Blood–Brain Barrier Damage to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model
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Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at implantation “window” of pregnant mice
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Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling.
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Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells
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Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549
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DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling
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Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo
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Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells
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Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells
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Epigenetic changes and functional study of HOXA11 in human gastric cancer
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Downregulation of FOXP3 inhibits invasion and immune escape in cholangiocarcinoma
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Overexpression of HMGB3 protein promotes cell proliferation, migration and is associated with poor prognosis in urinary bladder cancer patients
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Angiotensin II increases matrix metalloproteinase 2 expression in human aortic smooth muscle cells via AT1R and ERK1/2
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Angiotensin II Induces an Increase in Matrix Metalloproteinase 2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic Aneurysms via JNK, ERK1/2 and p38 MAPK Activation.
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Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling
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Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells
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Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells
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Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway.
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Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis
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Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles
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Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
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Knocking down Dp71 expression in A549 cells reduces its malignancy in vivo and in vitro
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(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity
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Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression
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Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages
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Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549
PMCID: Pubmed No.:25539072
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling
PMCID: Pubmed No.:25520862
Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo
PMCID: Pubmed No.:25201015
Oxymatrine targets EGFRp-Tyr845 and inhibits EGFR-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells
PMCID: Pubmed No.:25527205
Epigenetic Silencing of CXCL14 Induced Colorectal Cancer Migration and Invasion
PMCID: Pubmed No.:24099668
MicroRNA-29a promotes colorectal cancer metastasis by regulating matrix metalloproteinase 2 and E-cadherin via KLF4
PMCID: Pubmed No.:24281002
Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells
PMCID: Pubmed No.:26550465
Apelin induces vascular smooth muscle cells migration via a PI3K/Akt/FoxO3a/MMP-2 pathway.
PMCID: Pubmed No.:26494002
Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis
PMCID: Pubmed No.:26497626
Intermittent bout exercise training down-regulates age-associated inflammation in skeletal muscles
PMCID: Pubmed No.:26545590
Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
PMCID: Pubmed No.:26649143
Knocking down Dp71 expression in A549 cells reduces its malignancy in vivo and in vitro
PMCID: Pubmed No.:26691328
(-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity
PMCID: Pubmed No.:26821251
Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression
PMCID: Pubmed No.:26916087
Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
PMCID: Pubmed No.:24749816
Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial-mesenchymal transition and ILK signaling pathway
PMCID: Pubmed No.:24768914
Poloxamer-188 Can Attenuate Blood–Brain Barrier Damage to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model
PMCID: Pubmed No.:24770901
Abnormal expression of CDK11p58 in prostate cancer
PMCID: Pubmed No.:24397471
IDH1 Overexpression Induced Chemotherapy Resistance and IDH1 Mutation Enhanced Chemotherapy Sensitivity in Glioma Cells in Vitro and in Vivo
PMCID: Pubmed No.:24528069
Inhibition of metastatic tumor growth and metastasis via targeting metastatic breast cancer by chlorotoxin-modified liposomes
PMCID: Pubmed No.:24559485
Icaritin suppresses the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression
PMCID: Pubmed No.:24608674
Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway
PMCID: Pubmed No.:24637576
Activation of glucagon‐like peptide‐1 receptor inhibits tumourigenicity and metastasis of human pancreatic cancer cells via PI3K/Akt pathway
PMCID: Pubmed No.:24641303
Granulocyte/Macrophage Colony-Stimulating Factor Influences Angiogenesis by Regulating the Coordinated Expression of VEGF and the Ang/Tie System
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Strategy of STAT3β cell-specific expression in macrophages exhibits antitumor effects on mouse breast cancer
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provides growth and metastasis advantage for human hepatocellular carcinoma
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DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling
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Involvement of Oct4 in the pathogenesis of thoracic aortic dissection via inducing the dedifferentiated phenotype of human aortic smooth muscle cells by directly upregulating KLF5
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Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development
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lncRNA H19 regulates epithelial–mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA
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Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells
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Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis
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PT93, a novel caffeic acid amide derivative, suppresses glioblastoma cells migration, proliferation and MMP-2/-9 expression
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All-trans retinoic acid inhibits migration, invasion and proliferation, and promotes apoptosis in glioma cells in vitro
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Resveratrol suppresses human glioblastoma cell migration and invasion via activation of RhoA/ROCK signaling pathway
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Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells
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Emodin inhibits migration and invasion of MHCC‑97H human hepatocellular carcinoma cells
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Co-culture with lung cancer A549 cells promotes the proliferation and migration of mesenchymal stem cells derived from bone marrow
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Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma
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Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling
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Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development
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RNA m 6 A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail
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Different co-culture models reveal the pivotal role of TBBPA-promoted M2 macrophage polarization in the deterioration of endometrial cancer
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Methylation of NRN1 is a novel synthetic lethal marker of PI3K‐Akt‐mTOR and ATR inhibitors in esophageal cancer
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Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer
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Anticancer Effects of Gleditsia sinensis Extract in Rats Transplanted With Hepatocellular Carcinoma Cells
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Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma
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Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling
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Chinese herbal formula QHF inhibits hepatocellular carcinoma metastasis via HGF/c-Met signaling pathway
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Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-κB signalling pathway
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Up-regulation of PTEN via LPS/AP-1/NF-κB pathway inhibits trophoblast invasion contributing to preeclampsia
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Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug
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Long noncoding RNA NEAT1 promotes cell proliferation, migration, and invasion in hepatocellular carcinoma through interacting with miR‐384
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Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation
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Anticancer effects of Poncirus fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion
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Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling
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TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway
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O‑GlcNAc modification influences endometrial receptivity by promoting endometrial cell proliferation, migration and invasion
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The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma
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Chronic corticosterone exposure induces liver inflammation and fibrosis in association with m 6 A-linked post-transcriptional suppression of heat shock proteins in chicken
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4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts
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Plk1 promotes the migration of human lung adenocarcinoma epithelial cells via STAT3 signaling
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Pectin Oligosaccharides Enhance α2,6-Sialylation Modification that Promotes Apoptosis of Bladder Cancer Cells by Targeting the Hedgehog Pathway
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The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway
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IL-1β promotes the migration of olfactory epithelium neural stem cells through activating matrix metalloproteinase expressions
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Downregulation of astrocyte elevated gene‑1 expression inhibits the development of vasculogenic mimicry in gliomas
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Downregulation of Astrocyte Elevated Gene-1 Expression Combined with All-Trans Retinoic Acid Inhibits Development of Vasculogenic Mimicry and Angiogenesis in Glioma
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Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation
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Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.