JNK1+JNK2+JNK3 Polyclonal Antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
JNK1+JNK2+JNK3 Polyclonal Antibody Background :
JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53. JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity. Product :
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
JNK1+JNK2+JNK3 Polyclonal Antibody detects endogenous levels of JNK1+JNK2+JNK3 protein. Immunogen :
KLH conjugated synthetic peptide derived from human JNK1/2/3:151-250/384 Conjugate :
Unconjugated Modification :
Unmodification
JNK1+JNK2+JNK3 Polyclonal Antibody Background :
JNK1(MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53. JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity. Product :
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
JNK1+JNK2+JNK3 Polyclonal Antibody detects endogenous levels of JNK1+JNK2+JNK3 protein. Immunogen :
KLH conjugated synthetic peptide derived from human JNK1/2/3:151-250/384 Conjugate :
Unconjugated Modification :
Unmodification
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Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-JNK1+JNK2+JNK3 at 1/300 dilution -
Sample: Cerebrum(Rat) Lysate at 40 ug Cerebrum(Mouse) Lysate at 40 ug Heart(Rat) Lysate at 40 ug Heart(Mouse) Lysate at 40 ug Cerebellum(Rat) Lysate at 40 ug Cerebellum(Mouse) Lysate at 40 ug Primary: Anti-JNK1+JNK2+JNK3 at 1/1000 dilution -
Sample: Cerebrum(Rat) Lysate at 40 ug Cerebrum(Mouse) Lysate at 40 ug Heart(Rat) Lysate at 40 ug Heart(Mouse) Lysate at 40 ug Cerebellum(Rat) Lysate at 40 ug Cerebellum(Mouse) Lysate at 40 ug Primary: Anti-JNK1+JNK2+JNK3 at 1/1000 dilution
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Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.