Product Name :
MMP9 polyclonal antibody Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MMP9 polyclonal antibody detects endogenous levels of MMP9 protein. Immunogen :
Recombinant full length Human MMP9. Conjugate :
Unconjugated Modification :
Unmodification
MMP9 polyclonal antibody Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MMP9 polyclonal antibody detects endogenous levels of MMP9 protein. Immunogen :
Recombinant full length Human MMP9. Conjugate :
Unconjugated Modification :
Unmodification
-
Immunohistochemistry of paraffin-embedded mouse heart using MMP9 antibody at dilution of 1:100 (40x lens).
-
Immunohistochemistry of paraffin-embedded human liver damage using MMP9 antibody at dilution of 1:100 (40x lens).
-
Immunohistochemistry of paraffin-embedded human liver damage using MMP9 antibody at dilution of 1:100 (40x lens).
-
Immunohistochemistry of paraffin-embedded human liver damage using MMP9 antibody at dilution of 1:100 (40x lens).
Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling
PMCID: Pubmed No.:27374455
Toll like receptor 4 facilitates invasion and migration as a cancer stem cell marker in hepatocellular carcinoma
PMCID: Pubmed No.:25511737
Lipoxin A4 Attenuates Cell Invasion by Inhibiting ROS/ERK/MMP Pathway in Pancreatic Cancer
PMCID: Pubmed No.:26649143
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-β signaling
PMCID: Pubmed No.:26272184
Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis
PMCID: Pubmed No.:26497626
Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis
PMCID: Pubmed No.:26497626
Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells
PMCID: Pubmed No.:25872479
Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
PMCID: Pubmed No.:28774312
Methylation of DIRAS1 promotes colorectal cancer progression and may serve as a marker for poor prognosis
PMCID: Pubmed No.:28491151
Ulinastatin protects brain against cerebral ischemia/reperfusion injury through inhibiting MMP-9 and alleviating loss of ZO-1 and occludin proteins in mice
PMCID: Pubmed No.:29291404
Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages
PMCID: Pubmed No.:27144994
DACT2 is frequently methylated in human gastric cancer and methylation of DACT2 activated Wnt signaling
PMCID: Pubmed No.:25520862
Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development
PMCID: Pubmed No.:28678648
COMP-Ang1 prevents periodontitic damages and enhances mandible bone growth in an experimental animal model
PMCID: Pubmed No.:27612438
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages
PMCID: Pubmed No.:27325699
Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways
PMCID: Pubmed No.:28280123
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration
PMCID: Pubmed No.:27460424
Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver metastasis
PMCID: Pubmed No.:26275833
Korean Byungkyul - Citrus platymamma Hort.et Tanaka flavonoids induces cell cycle arrest and apoptosis, regulating MMP protein expression in Hep3B hepatocellular carcinoma cells
PMCID: Pubmed No.:28035361
Downregulation of FoxM1 inhibits proliferation, invasion and angiogenesis of HeLa cells in vitro and in vivo
PMCID: Pubmed No.:25201015
Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549
PMCID: Pubmed No.:25539072
Reno-protection of G004, a novel anti-diabetic sulfonylurea in db/db mice
PMCID: Pubmed No.:25943026
Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways
PMCID: Pubmed No.:26614458
MicroRNA-133a inhibits cell proliferation, colony formation ability, migration and invasion by targeting matrix metallopeptidase 9 in hepatocellular carcinoma
PMCID: Pubmed No.:25607810
Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells
PMCID: Pubmed No.:26318439
Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling
PMCID: Pubmed No.:25375359
Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway
PMCID: Pubmed No.:28454408
The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats
PMCID: Pubmed No.:27956237
Epb41l3 suppresses esophageal squamous cell carcinoma invasion and inhibits MMP2 and MMP9 expression
PMCID: Pubmed No.:26916087
Protection of Tong-Qiao-Huo-Xue Decoction against Cerebral Ischemic Injury through Reduction Blood–Brain Barrier Permeability
PMCID: Pubmed No.:29093286
Changes in the expression of Col IV, gelatinase and TIMP-1 in oral leukoplakia
PMCID: Pubmed No.:31966707
Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of Υ-synuclein in hepatocellular carcinoma cells
PMCID: Pubmed No.:28035067
Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells
PMCID: Pubmed No.:28424406
Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression
PMCID: Pubmed No.:27270327
LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma
PMCID: Pubmed No.:29228655
Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development
PMCID: Pubmed No.:29050260
Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer
PMCID: Pubmed No.:26396173
Different co-culture models reveal the pivotal role of TBBPA-promoted M2 macrophage polarization in the deterioration of endometrial cancer
PMCID: Pubmed No.:33609860
Methylation of NRN1 is a novel synthetic lethal marker of PI3K‐Akt‐mTOR and ATR inhibitors in esophageal cancer
PMCID: Pubmed No.:33931924
Long non-coding RNA MCM3AP-AS1 promotes growth and migration through modulating FOXK1 by sponging miR-138-5p in pancreatic cancer
PMCID: Pubmed No.:31830901
Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma
PMCID: Pubmed No.:30400968
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling
PMCID: Pubmed No.:33542902
Chinese herbal formula QHF inhibits hepatocellular carcinoma metastasis via HGF/c-Met signaling pathway
PMCID: Pubmed No.:33075668
c‐Fos separation from Lamin A/C by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment
PMCID: Pubmed No.:31613004
YiQiFuMai Lyophilized Injection ameliorates tPA-induced hemorrhagic transformation by inhibiting cytoskeletal rearrangement associated with ROCK1 and NF-κB signaling pathways
PMCID: Pubmed No.:32730882
Long noncoding RNA NEAT1 promotes cell proliferation, migration, and invasion in hepatocellular carcinoma through interacting with miR‐384
PMCID: Pubmed No.:30346062
Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model
PMCID: Pubmed No.:32711044
TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway
PMCID: Pubmed No.:31920328
The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma
PMCID: Pubmed No.:33381389
Pectin Oligosaccharides Enhance α2,6-Sialylation Modification that Promotes Apoptosis of Bladder Cancer Cells by Targeting the Hedgehog Pathway
PMCID: Pubmed No.:34041669
UBE2W down‐regulation promotes cell apoptosis and correlates with hypospermatogenesis
PMCID: Pubmed No.:31710394
Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling
PMCID: Pubmed No.:33488803
Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4–dependent manner
PMCID: Pubmed No.:35050463
Nodal Enhances Perineural Invasion in Pancreatic Cancer by Promoting Tumor-Nerve Convergence
PMCID: Pubmed No.:35126957
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.