Bax (S163) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
Bax (S163) polyclonal antibody Background :
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Bax (S163) polyclonal antibody detects endogenous levels of Bax protein. Immunogen :
Synthetic peptide, corresponding to amino acids 150-200 of Human Bax. Conjugate :
Unconjugated Modification :
Unmodification
Bax (S163) polyclonal antibody Background :
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Bax (S163) polyclonal antibody detects endogenous levels of Bax protein. Immunogen :
Synthetic peptide, corresponding to amino acids 150-200 of Human Bax. Conjugate :
Unconjugated Modification :
Unmodification
Sonic Hedgehog Protects Cortical Neurons Against Oxidative Stress
PMCID: Pubmed No.:20848190
Luteolin protects against reactive oxygen species-mediated cell death induced by zinc toxicity via the PI3K–Akt–NF-κB–ERK-dependent pathway
PMCID: Pubmed No.:21800350
Effect of interaction of magnetic nanoparticles of Fe3O4 and artesunate on apoptosis of K562 cells
PMCID: Pubmed No.:21822380
Treatment With Ginseng Total Saponins Reduces the Secondary Brain Injury in Rat After Cortical Impact
PMCID: Pubmed No.:22434648
Naringin Treatment Improves Functional Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury
PMCID: Pubmed No.:22453521
Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer
PMCID: Pubmed No.:22687635
NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK- dependent mitochondrial pathway
PMCID: Pubmed No.:22824464
Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3 infection and its potential role in cardiac fibrosis
PMCID: Pubmed No.:22867880
TGFβ1 Treatment Reduces Hippocampal Damage, Spontaneous Recurrent Seizures, and Learning Memory Deficits in Pilocarpine-Treated Rats
PMCID: Pubmed No.:22936246
S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats
PMCID: Pubmed No.:23427186
Qi-Dan Fang ameliorates adriamycin-induced nephrotic syndrome rat model by enhancing renal function and inhibiting podocyte injury
PMCID: Pubmed No.:24389029
Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells
PMCID: Pubmed No.:24484372
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells
PMCID: Pubmed No.:24722831
Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression
PMCID: Pubmed No.:25123535
Concentration-dependent differential effects of an epothilone analog on cell cycle and p53 signaling
PMCID: Pubmed No.:26177745
Protective Effect of l-Theanine on Cadmium-Induced Apoptosis in PC12 Cells by Inhibiting the Mitochondria-Mediated Pathway
PMCID: Pubmed No.:26164708
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
PMCID: Pubmed No.:26188509
Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway
PMCID: Pubmed No.:26460892
Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression
PMCID: Pubmed No.:25123535
Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway
PMCID: Pubmed No.:26460892
Qi-Dan Fang ameliorates adriamycin-induced nephrotic syndrome rat model by enhancing renal function and inhibiting podocyte injury
PMCID: Pubmed No.:24389029
Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells
PMCID: Pubmed No.:24484372
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells
PMCID: Pubmed No.:24722831
Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway
PMCID: Pubmed No.:26460892
Effect of Glycyrrhiza uralensis against ulcerative colitis through regulating the signaling pathway of FXR/P-gp
PMCID: Pubmed No.:34540046
Long noncoding RNA LINC00662‐miR‐15b‐5p mediated GPR120 dysregulation contributes to osteoarthritis
PMCID: Pubmed No.:32037689
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.