Tau (phospho-S396) polyclonal antibody 
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Product Name :
Tau (phospho-S396) polyclonal antibody Background :
Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
p-Tau (S396) polyclonal antibody detects endogenous levels of Tau only when phosphorylated at Ser713, isoforms Tau-4 phosphorylated at Ser396, and other isoforms phosphorylated at the corresponding Site. Immunogen :
Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Serine 396. Conjugate :
Unconjugated Modification :
Phosphorylation
Tau (phospho-S396) polyclonal antibody Background :
Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
p-Tau (S396) polyclonal antibody detects endogenous levels of Tau only when phosphorylated at Ser713, isoforms Tau-4 phosphorylated at Ser396, and other isoforms phosphorylated at the corresponding Site. Immunogen :
Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Serine 396. Conjugate :
Unconjugated Modification :
Phosphorylation
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Western blot (WB) analysis of Tau (phospho-S396) polyclonal antibody at 1:500 dilution Lane1:The Brain tissue lysate of Mouse(40ug) Lane2:The Brain tissue lysate of Rat(40ug) -
Immunohistochemistry (IHC) analyzes of p-Tau (S396) pAb in paraffin-embedded human breast carcinoma tissue
MicroRNA-26 Was Decreased in Rat Cardiac Hypertrophy Model and May Be a Promising Therapeutic Target.
PMCID: Pubmed No.:23719092
UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices
PMCID: Pubmed No.:24323362
Proteasome Inhibition-Induced Downregulation of Akt/GSK-3β Pathway Contributes to Abnormality of Tau in Hippocampal Slice
PMCID: Pubmed No.:24752588
Self-assembling nanofibers alter the processing of amyloid precursor protein in a transgenic mouse model of Alzheimer's disease
PMCID: Pubmed No.:25005263
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein
PMCID: Pubmed No.:26444754
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein
PMCID: Pubmed No.:26444754
Proteasome Inhibition-Induced Downregulation of Akt/GSK-3β Pathway Contributes to Abnormality of Tau in Hippocampal Slice
PMCID: Pubmed No.:24752588
UCH-L1 Inhibition Involved in CREB Dephosphorylation in Hippocampal Slices
PMCID: Pubmed No.:24323362
The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation
PMCID: Pubmed No.:28424976
Enhanced Tau Protein Translation by Hyper-Excitation
PMCID: Pubmed No.:31824301
Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation
PMCID: Pubmed No.:32711020
Ferroptosis promotes microtubule-associated protein tau aggregation via GSK-3β activation and proteasome inhibition
PMCID: Pubmed No.:34997541
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.