Product Name :
SMUG1 polyclonal antibody Background :
The base excision repair (BER) pathway removes incorrect bases (uracil) or damaged bases (3-methyladenine) from chromatin. Each BER enzyme system addresses a specific type of base damage. Uracil-DNA glycosylases, UNG2 and SMUG1 (single-strand selective monofunctional uracil DNA glycosylase) remove uracil from both double- and single-stranded DNA in nucleosomes (chromatin core particle). The uracil-excising enzyme family shares structural and functional conservation with minimal sequence conservation. The human SMUG1 gene maps to chromosome 12q13.13. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
SMUG1 polyclonal antibody detects endogenous levels of SMUG1 protein. Immunogen :
Synthetic peptide, corresponding to amino acids 137-182 of Human SMUG1. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of SMUG1 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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