Product Name :
IL-22Rα2 polyclonal antibody Background :
IL-22Rα2 (interleukin-22 receptor α-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22Rα2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22Rα2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22Rα2 may be important in regulating inflammatory responses. In addition, IL-22Rα2 can be induced by lipopolysaccharide (LPS). Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IL-22Rα2 polyclonal antibody detects endogenous levels of IL-22Rα2 protein. Immunogen :
A synthetic peptide corresponding to residues in Human IL-22Rα2. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of IL-22Rα2 polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:Mouse heart tissue lysate Lane3:Rat heart tissue lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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