Product Name :
IL37 polyclonal antibody Background :
IL-1 (Interleukin-1) is a cytokine responsible for initiating a variety of activities through the activation of transcription factors, NFκB and AP-1, thereby promoting host response to injury or infection. The IL-1 superfamily is comprised of several ligands and receptors. IL-1F7, also known as IL-1ζ, IL-1 homolog 4 (IL-1H4) or IL-1 related protein 1 (IL-1rp1), is a secreted ligand belonging to this superfamily. It is expressed in the cytoplasm of peripheral monocytic cells localizing to the inner surface of the plasma membrane and surrounding the nuclear membrane suggesting that IL-1F7 may play a role in immune regulation. Five isoforms exist for this protein due to alternative splicing and they are designated IL-1F7a through IL-1F7e. Isoform a has a distinct N-terminus while isoforms c-d are truncated. Isoform b is the mature functional isoform that binds to the IL-18Rα-chain and the IL-18 binding protein (IL-18BP) acting as an IL-18 antagonist. IL-1F7 is closely related to IL-1ra, sharing 36% sequence identity. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
IL37 polyclonal antibody detects endogenous levels of IL37 protein. Immunogen :
A synthetic peptide corresponding to residues in Human IL37. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of IL37 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:NIH-3T3 cell lysate Lane3:H9C2 cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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