PAK6 polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
PAK6 polyclonal antibody Background :
The p21(CDKN1A)-activated kinases (PAKs) are serine/threonine protein kinases that bind to activated small GTPases, including Cdc42 and Rac, and influence transcription, cell morphology (cytoskeleton rearrangement), motility, and apoptosis. PAK family members contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 transcripts are present at high levels in brain and testis, with lower levels in multiple tissues including prostate and breast. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
PAK6 polyclonal antibody detects endogenous levels of PAK6 protein. Immunogen :
A synthetic peptide corresponding to residues in Human PAK6. Conjugate :
Unconjugated Modification :
Unmodification
PAK6 polyclonal antibody Background :
The p21(CDKN1A)-activated kinases (PAKs) are serine/threonine protein kinases that bind to activated small GTPases, including Cdc42 and Rac, and influence transcription, cell morphology (cytoskeleton rearrangement), motility, and apoptosis. PAK family members contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 transcripts are present at high levels in brain and testis, with lower levels in multiple tissues including prostate and breast. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
PAK6 polyclonal antibody detects endogenous levels of PAK6 protein. Immunogen :
A synthetic peptide corresponding to residues in Human PAK6. Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of PAK6 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.