Product Name :
KCNE1L polyclonal antibody Background :
KCNE genes encode small, single transmembrane domain peptides that associate with pore-forming å-subunits to form K+ channels with unique characteristics. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNE1L (KCNE1-like), also known as KCNE5, potassium voltage-gated channel subfamily E member 1-like protein or AMMECR2, is a 142 amino acid single-pass type I membrane protein belonging to the potassium channel KCNE family. Defects of the KCNE1L gene have been linked to the cardiac and some neurological abnormalities observed in patients with AMME (Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis) contiguous gene syndrome. KCNE1L is primarily expressed in skeletal muscle, brain, placenta, spinal cord and heart. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
KCNE1L polyclonal antibody detects endogenous levels of KCNE1L protein. Immunogen :
A synthetic peptide corresponding to residues in Human KCNE1L. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of KCNE1L polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:MCF-7 whole cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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