Product Name :
MMP21 polyclonal antibody Background :
The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-21 is 569 amino acid residues in length and consists of a prodomain, catalytic domain, and haemopexin-like domain. It is the human orthologue for XMMP in X. laevis and CyMMP in C. pyrrhogaster. MMP-21 is expressed in various fetal and adult tissues. It a possible target gene of the Wnt pathway, and the expression of this protein is controlled by Pax and Notch transcription factors. MMP-21 may play an important role in embryogenesis, tissue development (particularly in the brain), tumor progression and possibly apoptosis. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
MMP21 polyclonal antibody detects endogenous levels of MMP21 protein. Immunogen :
A synthetic peptide corresponding to residues in Human MMP21 Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of MMP21 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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