TGFBR3 polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
TGFBR3 polyclonal antibody Background :
A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGFβ RIII (transforming growth factor beta receptor type 3), also known as TGFBR3 or TGFR-3, is an 850 amino acid secreted and single-pass type I membrane protein that contains one ZP domain and may assist in capturing TGFβ for presentation to signaling receptors.TGFβ RIII undergoes post-translational modification by glycosaminoglycan groups (GAG) and is encoded by a gene that maps to human chromosome 1p22.1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
TGFBR3 polyclonal antibody detects endogenous levels of TGFBR3 protein. Immunogen :
A synthetic peptide corresponding to residues in Human TGFBR3 Conjugate :
Unconjugated Modification :
Unmodification
TGFBR3 polyclonal antibody Background :
A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGFβ RIII (transforming growth factor beta receptor type 3), also known as TGFBR3 or TGFR-3, is an 850 amino acid secreted and single-pass type I membrane protein that contains one ZP domain and may assist in capturing TGFβ for presentation to signaling receptors.TGFβ RIII undergoes post-translational modification by glycosaminoglycan groups (GAG) and is encoded by a gene that maps to human chromosome 1p22.1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
TGFBR3 polyclonal antibody detects endogenous levels of TGFBR3 protein. Immunogen :
A synthetic peptide corresponding to residues in Human TGFBR3 Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of TGFBR3 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.