ITIH4 polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
ITIH4 polyclonal antibody Background :
The inter-α-trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-HI, ITI-H2 and ITI-H3) and one light chain (Bikunin). Another member of the ITI family, ITI-H4, harbors a proline-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. While the ITI family is primarily composed of multi-polypeptide molecules, ITI-H4 is a single chain molecule. Unlike other ITI family members, the gene transcriptions and products for rat and human ITI-H4 demonstrate marked differences, suggesting possible species-specific functions for ITI-H4. The gene encoding human ITI-H4 maps to chromosome 3p21.1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ITIH4 polyclonal antibody detects endogenous levels of ITIH4 protein. Immunogen :
A synthetic peptide corresponding to residues in Human ITIH4 Conjugate :
Unconjugated Modification :
Unmodification
ITIH4 polyclonal antibody Background :
The inter-α-trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-HI, ITI-H2 and ITI-H3) and one light chain (Bikunin). Another member of the ITI family, ITI-H4, harbors a proline-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. While the ITI family is primarily composed of multi-polypeptide molecules, ITI-H4 is a single chain molecule. Unlike other ITI family members, the gene transcriptions and products for rat and human ITI-H4 demonstrate marked differences, suggesting possible species-specific functions for ITI-H4. The gene encoding human ITI-H4 maps to chromosome 3p21.1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ITIH4 polyclonal antibody detects endogenous levels of ITIH4 protein. Immunogen :
A synthetic peptide corresponding to residues in Human ITIH4 Conjugate :
Unconjugated Modification :
Unmodification
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Western blot (WB) analysis of ITIH4 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.