Product Name :
ALDH18A1 polyclonal antibody Background :
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during the detoxification of alcohol-derived acetaldehyde, lipid peroxidation, and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH18A1 (aldehyde dehydrogenase 18 family member A1), also known as GSAS (glutamate γ-semialdehyde synthetase), P5CS (δ1- pyrroline-5-carboxylate synthetase) or PYCS, is the major enzyme involved in proline, arginine and ornithine biosynthesis. Localizing to the inner mitochondrial membrane, ALDH18A1 catalyzes the reduction of glutamate to δ1- pyrroline-5-carboxylate. Due to alternative splicing events, two isoforms exist for ALDH18A1, differing by only two amino acids. The longer isoform is widely expressed while the shorter isoform predominantly functions in the gut. A mutation in the gene encoding ALDH18A1 results in P5CS deficiency, a disease characterized by progressive joint laxity, neurodegeneration, bilateral subcapsular cataracts and skin hyperelasticity. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
ALDH18A1 pAb detects endogenous levels of ALDH18A1 protein. Immunogen :
Synthetic peptide, corresponding to Human ALDH18A1. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot (WB) analysis of ALDH18A1 pAb at 1:2000 dilution Lane1:The Embryo tissue lysate of Mouse(40ug) Lane2:A375 whole cell lysate(40ug) Lane3:HCT116 whole cell lysate(20ug)

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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