Product Name :
Actived-Caspase-3 p17 polyclonal antibody Background :
Caspase 3 (also known as CPP32, YAMA and apopain) is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10).The processed form of Caspase 3 consists of large (17kD) and small (12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 - Ser29 and Asp175 - Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Actived-Caspase-3 p17 polyclonal antibody detects endogenous levels of Actived-Caspase-3 p17 protein. Immunogen :
Synthetic peptide conjugated to KLH derived from within residues 150 - 200 of Human active Caspase 3. Conjugate :
Unconjugated Modification :
Unmodification
Actived-Caspase-3 p17 polyclonal antibody Background :
Caspase 3 (also known as CPP32, YAMA and apopain) is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10).The processed form of Caspase 3 consists of large (17kD) and small (12kD) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 - Ser29 and Asp175 - Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
Actived-Caspase-3 p17 polyclonal antibody detects endogenous levels of Actived-Caspase-3 p17 protein. Immunogen :
Synthetic peptide conjugated to KLH derived from within residues 150 - 200 of Human active Caspase 3. Conjugate :
Unconjugated Modification :
Unmodification
-
Western blot (WB) analysis of Actived-Caspase-3 p17 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:Hela treated with H2O2 (100nmol/ml, 25min, phostop) whole cell lysate (40ug) Lane3:Hela treated with H2O2 (100nmol/ml, 25min, λ-ppase) whole cell lysate (40ug)
-
Immunohistochemistry (IHC) analyzes of Actived-Caspase-3 p17 pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Suppression of epithelial–mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells
PMCID: Pubmed No.:25501598
Loss of KLF14 triggers centrosome amplification and tumorigenesis
PMCID: Pubmed No.:26439168
Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells
PMCID: Pubmed No.:27463126
CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response
PMCID: Pubmed No.:28837156
Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition
PMCID: Pubmed No.:28619062
Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats
PMCID: Pubmed No.:28359892
Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress
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Adiponectin reduces ER stress-induced apoptosis through PPAR α transcriptional regulation of ATF2 in mouse adipose
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Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
PMCID: Pubmed No.:26203862
RN181 suppressed tumor growth of hepatocellular carcinoma by inhibition of the ERK/MAPK pathway
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ZL11n is a novel nitric oxide-releasing derivative of farnesylthiosalicylic acid that induces apoptosis in human hepatoma HepG2 cells via MAPK/mitochondrial pathways
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Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats
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Mesenchymal stem cells derived from Wharton jelly of the human umbilical cord ameliorate damage to human endometrial stromal cells
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HnRNPL as a key factor in spermatogenesis: Lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome
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MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer
PMCID: Pubmed No.:22388101
Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer
PMCID: Pubmed No.:22687635
Effects of PEG-liposomal oxaliplatin on apoptosis, and expression of Cyclin A and Cyclin D1 in colorectal cancer cells.
PMCID: Pubmed No.:22710431
Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury
PMCID: Pubmed No.:22716961
NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK- dependent mitochondrial pathway
PMCID: Pubmed No.:22824464
Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
PMCID: Pubmed No.:23026832
MicroRNA-145 Protects Cardiomyocytes against Hydrogen Peroxide (H2O2)-Induced Apoptosis through Targeting the Mitochondria Apoptotic Pathway
PMCID: Pubmed No.:23028672
Phycocyanin may suppress d-galactose-induced human lens epithelial cell apoptosis through mitochondrial and unfolded protein response pathways
PMCID: Pubmed No.:23036742
Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma
PMCID: Pubmed No.:23052483
Herbacetin induces apoptosis in HepG2 Cells: Involvements of ROS and PI3K/Akt pathway
PMCID: Pubmed No.:23063593
T63, a New 4-Arylidene Curcumin Analogue induces cell cycle arrest and apoptosis through activation of Reactive Oxygen Species-FOXO3a pathway in lung cancer cells
PMCID: Pubmed No.:23085518
The Combined Effects of Hematoporphyrin Monomethyl Ether-SDT and Doxorubicin on the Proliferation of QBC939 Cell Lines
PMCID: Pubmed No.:23200181
MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells
PMCID: Pubmed No.:23220614
Osteopontin Splice Variants Differentially Exert Clinicopathological Features and Biological Functions in Gastric Cancer
PMCID: Pubmed No.:23289017
Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo
PMCID: Pubmed No.:23425941
[Gly14]-Humanin Offers Neuroprotection through Glycogen Synthase Kinase-3β Inhibition in a Mouse Model of Intracerebral Hemorrhage
PMCID: Pubmed No.:23538063
Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodeling
PMCID: Pubmed No.:23933320
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice
PMCID: Pubmed No.:23993977
ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione
PMCID: Pubmed No.:24036456
Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model.
PMCID: Pubmed No.:24122153
Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury
PMCID: Pubmed No.:None
The Combination of Proteasome Inhibitors Bortezomib and Gambogic Acid Triggers Synergistic Cytotoxicity in vitro but not in vivo
PMCID: Pubmed No.:24291039
Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury
PMCID: Pubmed No.:24335166
Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line
PMCID: Pubmed No.:24374571
Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
PMCID: Pubmed No.:24373880
Molecular Mechanisms of Exopolysaccharide from Aphanothece halaphytica (EPSAH) Induced Apoptosis in HeLa Cells
PMCID: Pubmed No.:24466342
Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p. Gly1170Ser Mutated Mouse Model
PMCID: Pubmed No.:24475193
Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade
PMCID: Pubmed No.:24619207
ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
PMCID: Pubmed No.:24624962
Selective inhibition of protein kinase C β2 attenuates the adaptor P66Shc-mediated intestinal ischemia–reperfusion injury
PMCID: Pubmed No.:24722289
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells
PMCID: Pubmed No.:24722831
Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation
PMCID: Pubmed No.:24788079
Paraspeckle Protein 1 (PSPC1) Is Involved in the Cisplatin Induced DNA Damage Response—Role in G1/S Checkpoint
PMCID: Pubmed No.:24819514
Isoorientin induces apoptosis and autophagy simultaneously by ROS-related P53, PI3K/Akt, JNK and P38 signaling pathways in HepG2 cancer cells
PMCID: Pubmed No.:24841907
Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway
PMCID: Pubmed No.:24930012
Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways.
PMCID: Pubmed No.:24989893
Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway.
PMCID: Pubmed No.:25224805
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
PMCID: Pubmed No.:25501598
Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators.
PMCID: Pubmed No.:25545984
Protective efficacy of carnosic acid against hydrogen peroxide (H2O2)-induced oxidative injury in HepG2 cells through SIRT1 pathway
PMCID: Pubmed No.:26059423
Activation of cellular apoptosis in the cecal epithelium is associated with increased oxidative reactions in lactating goats following high concentrate diet feeding
PMCID: Pubmed No.:25590230
Neuroprotection by peripheral nerve electrical stimulation and remote postconditioning against acute experimental ischaemic stroke
PMCID: Pubmed No.:25819636
NOAD, a novel nitric oxide donor, induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells
PMCID: Pubmed No.:26001517
Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mice pre-adipocyte
PMCID: Pubmed No.:26113535
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-cells from ER-Stress-Mediated Apoptosis.
PMCID: Pubmed No.:26157144
Salinomycin radiosensitizes human nasopharyngeal carcinoma cell line CNE-2 to radiation
PMCID: Pubmed No.:26209294
Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells.
PMCID: Pubmed No.:26204324
Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
PMCID: Pubmed No.:26203862
Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes
PMCID: Pubmed No.:26257270
Tert-butylhydroquinone Ameliorates Early Brain Injury After Experimental Subarachnoid Hemorrhage in Mice by Enhancing Nrf2-Independent Autophagy
PMCID: Pubmed No.:26260377
Loss of KLF14 triggers centrosome amplification and tumorigenesis.
PMCID: Pubmed No.:26439168
The molecular mechanisms of XBP-1 gene silencing on IRE1α-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress
PMCID: Pubmed No.:26796273
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis
PMCID: Pubmed No.:26676572
STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane
PMCID: Pubmed No.:26694943
Persistent mitoKATP Activation Is Involved in the Isoflurane-induced Cytotoxicity
PMCID: Pubmed No.:26803495
Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.
PMCID: Pubmed No.:26980009
Autophagy Regulates Intracerebral Hemorrhage Induced Neural Damage via Apoptosis and NF-κB Pathway
PMCID: Pubmed No.:26964766
A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy
PMCID: Pubmed No.:27086925
Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway.
PMCID: Pubmed No.:25224805
Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells.
PMCID: Pubmed No.:25501598
Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators.
PMCID: Pubmed No.:25545984
Anti-Necroptosis Chemical Necrostatin-1 Can Also Suppress Apoptotic and Autophagic Pathway to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model.
PMCID: Pubmed No.:24122153
Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury
PMCID: Pubmed No.:None
Loss of KLF14 triggers centrosome amplification and tumorigenesis.
PMCID: Pubmed No.:26439168
The molecular mechanisms of XBP-1 gene silencing on IRE1α-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress
PMCID: Pubmed No.:26796273
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis
PMCID: Pubmed No.:26676572
STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane
PMCID: Pubmed No.:26694943
Persistent mitoKATP Activation Is Involved in the Isoflurane-induced Cytotoxicity
PMCID: Pubmed No.:26803495
Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune and Inflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.
PMCID: Pubmed No.:26980009
Autophagy Regulates Intracerebral Hemorrhage Induced Neural Damage via Apoptosis and NF-κB Pathway
PMCID: Pubmed No.:26964766
A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy
PMCID: Pubmed No.:27086925
Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation
PMCID: Pubmed No.:24788079
Paraspeckle Protein 1 (PSPC1) Is Involved in the Cisplatin Induced DNA Damage Response—Role in G1/S Checkpoint
PMCID: Pubmed No.:24819514
The Combination of Proteasome Inhibitors Bortezomib and Gambogic Acid Triggers Synergistic Cytotoxicity in vitro but not in vivo
PMCID: Pubmed No.:24291039
Hypoxia-Inducible Factor-1α Dependent Pathways Mediate the Renoprotective Role of Acetazolamide Against Renal Ischemia-Reperfusion Injury
PMCID: Pubmed No.:24335166
Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line
PMCID: Pubmed No.:24374571
Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
PMCID: Pubmed No.:24373880
Molecular Mechanisms of Exopolysaccharide from Aphanothece halaphytica (EPSAH) Induced Apoptosis in HeLa Cells
PMCID: Pubmed No.:24466342
Endoplasmic Reticulum Stress-Unfolding Protein Response-Apoptosis Cascade Causes Chondrodysplasia in a col2a1 p. Gly1170Ser Mutated Mouse Model
PMCID: Pubmed No.:24475193
Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade
PMCID: Pubmed No.:24619207
ZnO nanoparticle-induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
PMCID: Pubmed No.:24624962
Selective inhibition of protein kinase C β2 attenuates the adaptor P66Shc-mediated intestinal ischemia–reperfusion injury
PMCID: Pubmed No.:24722289
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells
PMCID: Pubmed No.:24722831
Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
PMCID: Pubmed No.:28279221
Persistent mitoKATP Activation Is Involved in the Isoflurane-induced Cytotoxicity
PMCID: Pubmed No.:26803495
Methylation of DIRAS1 promotes colorectal cancer progression and may serve as a marker for poor prognosis
PMCID: Pubmed No.:28491151
Di-(2-ethylhexyl) phthalate induces apoptosis of GC-2spd cells via TR4/Bcl-2 pathway
PMCID: Pubmed No.:27084994
Enhancing the anti-multiple myeloma efficiency in a cancer stem cell xenograft model by conjugating the ABCG2 antibody with microbubbles for a targeted delivery of ultrasound mediated epirubicin
PMCID: Pubmed No.:28232025
The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis
PMCID: Pubmed No.:26676572
Diazoxide protects L6 skeletal myoblasts from H2O2-induced apoptosis via the phosphatidylinositol-3 kinase/Akt pathway
PMCID: Pubmed No.:26525360
Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes
PMCID: Pubmed No.:26113535
Zeaxanthin improves diabetes-induced cognitive deficit in rats through activiting PI3K/AKT signaling pathway
PMCID: Pubmed No.:28599877
RETRACTED ARTICLE: Advanced oxidation protein products induce chondrocyte death through a redox-dependent, poly (ADP-ribose) polymerase-1-mediated pathway
PMCID: Pubmed No.:27858200
NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K/Akt/GSK3β and ERK1/2 Pathways
PMCID: Pubmed No.:28762104
Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway
PMCID: Pubmed No.:26964766
The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy
PMCID: Pubmed No.:29277549
A novel small molecule compound diaporine inhibits breast cancer cell proliferation via promoting ROS generation
PMCID: Pubmed No.:27543689
The molecular mechanisms of XBP-1 gene silencing on IRE1α-TRAF2-ASK1-JNK pathways in oral squamous cell carcinoma under endoplasmic reticulum stress
PMCID: Pubmed No.:26796273
Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5′-monophosphate-activated protein kinase pathway
PMCID: Pubmed No.:27412517
NOAD, a novel nitric oxide donor, induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma Bel-7402 cells
PMCID: Pubmed No.:26001517
Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway
PMCID: Pubmed No.:28734031
Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: In vitro and in vivo effects of TrkA pathway activators
PMCID: Pubmed No.:25545984
Up-regulation of Tight-Junction Proteins by p38 Mitogen-Activated Protein Kinase/p53 Inhibition Leads to a Reduction of Injury to the Intestinal Mucosal Barrier in Severe Acute Pancreatitis
PMCID: Pubmed No.:27171513
The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke
PMCID: Pubmed No.:28916471
Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells
PMCID: Pubmed No.:26204324
Comparative proteomic profiling and possible toxicological mechanism of acute injury induced by carbon ion radiation in pubertal mice testes
PMCID: Pubmed No.:26257270
Annosquacin B induces mitochondrial apoptosis in multidrug resistant human breast cancer cell line MCF-7/ADR through selectively modulating MAPKs pathways
PMCID: Pubmed No.:27450387
Activation of cellular apoptosis in the caecal epithelium is associated with increased oxidative reactions in lactating goats after feeding a high-concentrate diet
PMCID: Pubmed No.:25590230
Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells
PMCID: Pubmed No.:27907038
TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer
PMCID: Pubmed No.:28855498
Neuroprotection by peripheral nerve electrical stimulation and remote postconditioning against acute experimental ischaemic stroke
PMCID: Pubmed No.:25819636
Curcumin improves the paclitaxel‑induced apoptosis of HPV‑positive human cervical cancer cells via the NF‑κB‑p53‑caspase‑3 pathway
PMCID: Pubmed No.:25780454
Triptolide exerts pro-apoptotic and cell cycle arrest activity on drug-resistant human lung cancer A549/Taxol cells via modulation of MAPK and PI3K/Akt signaling pathways
PMCID: Pubmed No.:27900040
Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism
PMCID: Pubmed No.:25394852
17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway
PMCID: Pubmed No.:27847386
Combined therapeutic effects of bortezomib and anacardic acid on multiple myeloma cells via activation of the endoplasmic reticulum stress response
PMCID: Pubmed No.:27430733
Emodin promotes the arrest of human lymphoma Raji cell proliferation through the UHRF1‑DNMT3A‑∆Np73 pathways
PMCID: Pubmed No.:28901428
Reducing Smad3/ATF4 was essential for Sirt1 inhibiting ER stress-induced apoptosis in mice brown adipose tissue
PMCID: Pubmed No.:28030827
A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers
PMCID: Pubmed No.:28968984
Novel mutations in the RB1 gene from Chinese families with a history of retinoblastoma
PMCID: Pubmed No.:25424699
Curdione Inhibits Proliferation of MCF-7 Cells by Inducing Apoptosis
PMCID: Pubmed No.:25520141
Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development
PMCID: Pubmed No.:29050260
Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes
PMCID: Pubmed No.:29221131
Salinomycin radiosensitizes human nasopharyngeal carcinoma cell line CNE-2 to radiation
PMCID: Pubmed No.:26209294
Alteration of MDM2 by the Small Molecule YF438 Exerts Antitumor Effects in Triple-Negative Breast Cancer
PMCID: Pubmed No.:33985974
The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation
PMCID: Pubmed No.:33397932
Resveratrol improves human umbilical cord-derived mesenchymal stem cells repair for cisplatin-induced acute kidney injury
PMCID: Pubmed No.:30237401
Di(n-butyl) phthalate exposure impairs meiotic competence and development of mouse oocyte
PMCID: Pubmed No.:30605815
Arsenic and sulfur dioxide co-exposure induce renal injury via activation of the NF-κB and caspase signaling pathway
PMCID: Pubmed No.:30825854
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy
PMCID: Pubmed No.:31864387
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53‐induced glycolysis and apoptosis regulator (TIGAR)‐mediated apoptosis, autophagy, and DNA damage
PMCID: Pubmed No.:30710454
MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation
PMCID: Pubmed No.:29511169
Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion
PMCID: Pubmed No.:34539141
A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growth
PMCID: Pubmed No.:30527624
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease
PMCID: Pubmed No.:30157869
Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome
PMCID: Pubmed No.:30633969
Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells
PMCID: Pubmed No.:33663206
Egg Yolk Immunoglobulin Supplementation Prevents Rat Liver from Aflatoxin B1-Induced Oxidative Damage and Genotoxicity
PMCID: Pubmed No.:30449111
The loss of dopaminergic neurons in DEC1 deficient mice potentially involves the decrease of PI3K/Akt/GSK3β signaling
PMCID: Pubmed No.:31884423
miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/β-catenin/ATF6 pathway in preadipocytes
PMCID: Pubmed No.:29483204
Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia‐inducible factor 1α/hedgehog pathway under hypoxia
PMCID: Pubmed No.:30790292
γ-glutamylcysteine suppresses cadmium-induced apoptosis in PC12 cells via regulating oxidative stress
PMCID: Pubmed No.:34767868
Apoptosis Induction by Iron Radiation via Inhibition of Autophagy in Trp53+/-Mouse Testes: Is Chronic Restraint-Induced Stress a Modifying Factor?
PMCID: Pubmed No.:29989073
Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis
PMCID: Pubmed No.:30972178
Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl4-Induced Liver Injury through Antioxidant Effect
PMCID: Pubmed No.:29686713
Control of preadipocyte proliferation, apoptosis and early adipogenesis by the forkhead transcription factor FoxO6
PMCID: Pubmed No.:33290791
β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest
PMCID: Pubmed No.:32457882
Phosphatidylinositol 3-Kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis
PMCID: Pubmed No.:30448607
Neuroprotective effect of resveratrol against radiation after surgically induced brain injury by reducing oxidative stress, inflammation, and apoptosis through NRf2/HO‐1/NF‐κB signaling pathway
PMCID: Pubmed No.:32815255
Transcobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers
PMCID: Pubmed No.:30100732
Synergistic effect of glycated chitosan and photofrin photodynamic therapy on different breast tumor model
PMCID: Pubmed No.:32485403
Hydrogen sulfide protects H9c2 cardiomyoblasts against H2O2-induced apoptosis
PMCID: Pubmed No.:30994729
-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-B Signaling in Colon Cancer Cells
PMCID: Pubmed No.:30363706
Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2
PMCID: Pubmed No.:35543148
CircPLXNA2 Affects the Proliferation and Apoptosis of Myoblast through circPLXNA2/gga-miR-12207-5P/MDM4 Axis
PMCID: Pubmed No.:36982536
Pioglitazone protects PC12 cells against oxidative stress injury: An in vitro study of its antiapoptotic effects via the PPARγ pathway
PMCID: Pubmed No.:37854503
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide(0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.