Product Name :
DRD5 polyclonal antibody Background :
D5DR (dopamine receptor D5, DR1B, DRD1L2) is a G protein-coupled receptor of the D1-like family that stimulates adenylyl cyclase and has a 10-fold higher affinity for dopamine than the D1 subtype. D5DR is present in neurons in the limbic regions of the brain. D5DR mRNA is most abundant in discrete cortical areas (layers II, IV and VI), the dentate gyrus and hippocampal subfields with low levels in the striatum. There are five major types of dopamine receptors. All are G protein-coupled metabotropic receptors, and can be excitatory or inhibitory to the post-synaptic neuron. D1 (D1A, D1C, D1D) and D5 (D1B) receptors belong to the D1-like receptor family. The D2, D3 and D4 receptors belong to the D2-like receptor family. Activation of the D1-like family receptors couples to increases in cAMP and is typically excitatory, while D2-like activation reduces cAMP and is typically inhibitory. Significant age-related decline in dopamine receptor mRNAs occurs in the hippocampus and entorhinal cortex. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
DRD5 polyclonal antibody detects endogenous levels of DRD5 protein. Immunogen :
Recombinant full length Human DRD5. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot analysis of DRD5 polyclonal antibody

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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