CBX4 polyclonal antibody 
Datasheet
COA
MSDS
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Product Name :
CBX4 polyclonal antibody Background :
Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein MPc2, also known as CBX4, PC2 or HPc2, maps to human chromosome 17q25.3. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. MPc2 is a repressor of proto-oncogene activity, thus interference with MPc2 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation. MPc2 is able to act as a long range transcriptional silencer. MPc2 is expressed in the human osteosarcoma cell line U-20S. MPc2 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CBX4 polyclonal antibody detects endogenous levels of CBX4 protein. Immunogen :
Recombinant full length Human CBX4. Conjugate :
Unconjugated Modification :
Unmodification
CBX4 polyclonal antibody Background :
Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein MPc2, also known as CBX4, PC2 or HPc2, maps to human chromosome 17q25.3. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. MPc2 is a repressor of proto-oncogene activity, thus interference with MPc2 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation. MPc2 is able to act as a long range transcriptional silencer. MPc2 is expressed in the human osteosarcoma cell line U-20S. MPc2 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
CBX4 polyclonal antibody detects endogenous levels of CBX4 protein. Immunogen :
Recombinant full length Human CBX4. Conjugate :
Unconjugated Modification :
Unmodification
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WesternBlot (WB) analysis of CBX4 polyclonal antibody -
Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition
PMCID: Pubmed No.:26918056
Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition
PMCID: Pubmed No.:26918056
Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition
PMCID: Pubmed No.:26918056
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.