Product Name :
UCN2 polyclonal antibody Background :
Two major regulatory peptides were originally isolated from fish urophysial extracts, Urotensin I and II . In both frog and human, the Urotensin II sequence is located at the carboxy-terminal position of the precursor . Human Urotensin II is composed of only 11 amino acid residues, while fish and frog Urotensin II possess 12 and 13 amino acid residues, respectively. The cyclic region of Urotensin II, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human. However, several substitutions have occurred in the amino-terminal region of the molecule . A human G protein-coupled receptor, GPR14, is the Urotensin II receptor . Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates. Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
UCN2 polyclonal antibody detects endogenous levels of UCN2 protein. Immunogen :
Recombinant full length Human UCN2. Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot analysis of extracts of rat skin cells, using UCN2 antibody.
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  Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens).
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  Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody at dilution of 1:100 (40x lens).

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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