HC-II (D68) polyclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
HC-II (D68) polyclonal antibody Background :
Heparin cofactor II (HCII) is a glycoprotein in human plasma which rapidly inactivates Thrombin in the presence of dermatan sulfate. Inhibition occurs by formation of a stable equimolar complex between HCII and Thrombin. Certain clinical conditions, such as hepatic failure, disseminated intravascular coagulation, thalasemina and sickle cell anemia, display reduced levels of HCII. However, during pregnancy, physiological levels of HCII expression are elevated. HCII may regulate coagulation and may participate in processes such as inflammation, atherosclerosis and wound repair. HCII is widely distributed among vertebrates and may have a common function in birds, amphibians and mammals. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
HC-II (D68) polyclonal antibody detects endogenous levels of HC-II protein. Immunogen :
Synthetic peptide, corresponding to amino acids 41-90 of Human HC-II. Conjugate :
Unconjugated Modification :
Unmodification
HC-II (D68) polyclonal antibody Background :
Heparin cofactor II (HCII) is a glycoprotein in human plasma which rapidly inactivates Thrombin in the presence of dermatan sulfate. Inhibition occurs by formation of a stable equimolar complex between HCII and Thrombin. Certain clinical conditions, such as hepatic failure, disseminated intravascular coagulation, thalasemina and sickle cell anemia, display reduced levels of HCII. However, during pregnancy, physiological levels of HCII expression are elevated. HCII may regulate coagulation and may participate in processes such as inflammation, atherosclerosis and wound repair. HCII is widely distributed among vertebrates and may have a common function in birds, amphibians and mammals. Product :
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
HC-II (D68) polyclonal antibody detects endogenous levels of HC-II protein. Immunogen :
Synthetic peptide, corresponding to amino acids 41-90 of Human HC-II. Conjugate :
Unconjugated Modification :
Unmodification
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Immunohistochemistry (IHC) analyzes of HC-II (D68) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.