SMYD1 monoclonal antibody 
Datasheet
COA
MSDS
SHIP
Product Name :
SMYD1 monoclonal antibody Background :
SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development. Product :
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This antibody detects endogenous levels of SMYD1 and does not cross-react with related proteins Immunogen :
Recombinant full length Human SMYD1. Conjugate :
Unconjugated Modification :
Unmodification
SMYD1 monoclonal antibody Background :
SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development. Product :
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This antibody detects endogenous levels of SMYD1 and does not cross-react with related proteins Immunogen :
Recombinant full length Human SMYD1. Conjugate :
Unconjugated Modification :
Unmodification
-
Western blot detection of SMYD1 in rat skeletal muscle lysates and using SMYD1 antibody (1:2000 diluted) .
Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.
Price/Size :
USD 368/1mg/vial
Tips:
For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).Describe :
Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.Formula:
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.
Storage:
The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C.
Note :
This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.