Product Name :
CTHRC1 monoclonal antibody Background :
CTHRC1 (collagen triple helix repeat containing 1) is a 243 amino acid secreted protein that localizes to the extracellular matrix and contains one collagen-like domain. Expressed as two alternatively spliced isoforms, the first of which is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, CTHRC1 is thought to function as a negative regulator of collagen matrix deposition and may also play a role in the stabilization of ligand-receptor interactions in the Wnt pathway. CTHRC1 is widely present in a variety of cancers, including melanoma and breast carcinoma, and may participate in cancer cell migration and cancer tissue invasion and metastasis. The gene encoding CTHRC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Product :
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Storage&Stability :
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Specificity :
CTHRC1 monoclonal antibody detects endogenous levels of CTHRC1 protein. Immunogen :
Recombinant protein Conjugate :
Unconjugated Modification :
Unmodification

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  Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.
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  Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

Bioworld Biotech only provide peptides for our antibodies and do not provide additional peptide customization services.

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Price/Size :

USD 368/1mg/vial

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Tips: 

For phospho antibody, we provide phospho peptide（0.5mg) and non-phospho peptide(0.5mg).

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Describe :

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (WB) and Immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or IHC performed with the neutralized antibody.

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Formula:

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.The purity is >90%,tested by HPLC and MS.

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Storage:

The freeze-dried powder is more stable. For short time at 2-8°C. For long term storage store at -20°C. 

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Note :

This product is for research use only (RUO only). Not for use in diagnostic or therapeutic procedures.

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