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Recombinant Murine Interleukin-1 beta (rMuIL-1β ) PR2020
RecombinantRecombinant Murine Interleukin-1 beta (rMuIL-1β )
Catalog No.PR2020
SourceEscherichia coli.
Molecular WeightApproximately 17.5kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Purity>98% by SDS-PAGE and HPLC analyses.
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationLyophilized from a 0.2mm filtered solution in PBS, pH 7.4.
EndotoxinLess than 1EU/mg of rmIL-1β as determined by LAL method.
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Recombinant :
Recombinant Murine Interleukin-1 beta (rMuIL-1β )
Source :
Escherichia coli.
Molecular Weight :
Approximately 17.5kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.
Purity :
>98% by SDS-PAGE and HPLC analyses.
Biological Activity :
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.002 ng/ml, corresponding to a specific activity of > 5 x 108 units/mg.
Physical Appearance :
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation :
Lyophilized from a 0.2mm filtered solution in PBS, pH 7.4.
AA Sequence :
MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
Endotoxin :
Less than 1EU/mg of rmIL-1β as determined by LAL method.
Reconstitution :
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage :
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Usage :
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China
Description :
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.
Blocking peptide available as PR2020P
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