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Recombinant Rat Interleukin 21 (rRtIL-21) PR3010
RecombinantRecombinant Rat Interleukin 21 (rRtIL-21)
Catalog No.PR3010
SourceEscherichia coli.
Molecular WeightApproximately 15.2 kDa, a single non-glycosylated polypeptide chain containing 129 amino acids.
Purity>95% by SDS-PAGE and HPLC analyses.
Biological ActivityMeasured by its ability to inhibit IL21dependent proliferation of N1186 human T cells. The ED50 for this effect is typically 1-5μg/mL in the presence of 50 ng/mL of recombinant mouse IL21.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationLyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4
EndotoxinLess than 1EU/μg of rRtIL-21 as determined by LAL method.
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10µg $298
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Recombinant :
Recombinant Rat Interleukin 21 (rRtIL-21)
Source :
Escherichia coli.
Molecular Weight :
Approximately 15.2 kDa, a single non-glycosylated polypeptide chain containing 129 amino acids.
Purity :
>95% by SDS-PAGE and HPLC analyses.
Biological Activity :
Measured by its ability to inhibit IL21dependent proliferation of N1186 human T cells. The ED50 for this effect is typically 1-5μg/mL in the presence of 50 ng/mL of recombinant mouse IL21.
Physical Appearance :
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation :
Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4
AA Sequence :
HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS
Endotoxin :
Less than 1EU/μg of rRtIL-21 as determined by LAL method.
Reconstitution :
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage :
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Usage :
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. Made in China
Description :
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Blocking peptide available as PR3010P
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