ABL1 (A198) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
ABL1 (A198) Peptide Applications :
Blocking Background :
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac. Alternative Name :
ABL1; ABL; JTK7; p150; Proto-oncogene c-Abl; Tyrosine-protein kinase ABL1; c-Abl Swiss-Prot :
P00519 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ABL1 (A198). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0377 ABL1 (A198) pAb.
ABL1 (A198) Peptide Applications :
Blocking Background :
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac. Alternative Name :
ABL1; ABL; JTK7; p150; Proto-oncogene c-Abl; Tyrosine-protein kinase ABL1; c-Abl Swiss-Prot :
P00519 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide ABL1 (A198). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0377 ABL1 (A198) pAb.
Blocking peptide available as AP0377PP