53BP1 (D2) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
53BP1 (D2) Peptide Applications :
Blocking Background :
The p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA-binding domain of wild type p53, but do not bind mutant p53. The central DNA-binding domain of p53 is required for site-specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site-specific binding also suggests that 53BP1 and 53BP2 are involved in p53-mediated tumor suppression. 53BP1 was isolated from H258 cells and is expressed in Jurkat cells in both the cytoplasm and the nucleus. The N-terminus of 53BP2 is localized to the cytoplasm, while the C-terminus might be localized in the nucleus. 53BP1 promotes cell proliferation by binding to p202, whereas 53BP2 induces cell death by binding to Bcl2 and NFkB p65. Alternative Name :
Tumor suppressor p53-binding protein 1; 53 BP1; p53-binding protein 1; p53BP1; TP53BP1; p53-BP1; Swiss-Prot :
Q12888 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 53BP1 (D2). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0418 53BP1 (D2) pAb.
53BP1 (D2) Peptide Applications :
Blocking Background :
The p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA-binding domain of wild type p53, but do not bind mutant p53. The central DNA-binding domain of p53 is required for site-specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site-specific binding also suggests that 53BP1 and 53BP2 are involved in p53-mediated tumor suppression. 53BP1 was isolated from H258 cells and is expressed in Jurkat cells in both the cytoplasm and the nucleus. The N-terminus of 53BP2 is localized to the cytoplasm, while the C-terminus might be localized in the nucleus. 53BP1 promotes cell proliferation by binding to p202, whereas 53BP2 induces cell death by binding to Bcl2 and NFkB p65. Alternative Name :
Tumor suppressor p53-binding protein 1; 53 BP1; p53-binding protein 1; p53BP1; TP53BP1; p53-BP1; Swiss-Prot :
Q12888 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 53BP1 (D2). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0418 53BP1 (D2) pAb.
Blocking peptide available as AP0418PP