IkB-α (Y42) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
IkB-α (Y42) Peptide Applications :
Blocking Background :
Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation Serines 32 and 36. IKKα appears to be critical for NFκB activation in response to proinflammatory cytokines. Phosphorylation of IκB by IKKα is stimulated by the NFκB inducing kinase (NIK), which itself is a central regulator for NFκB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ , and each appear to make essential contributions to IκB phosphorylation. Alternative Name :
I kappa B alpha; I kappa B alpha; I(Kappa)B(alpha); I(Kappa)B(alpha); I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA; IKBA; IKBalpha; MAD 3; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBI; NFKBIA; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B c Swiss-Prot :
P25963 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IkB-α (Y42). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0643 IkB-α (Y42) pAb.
IkB-α (Y42) Peptide Applications :
Blocking Background :
Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation Serines 32 and 36. IKKα appears to be critical for NFκB activation in response to proinflammatory cytokines. Phosphorylation of IκB by IKKα is stimulated by the NFκB inducing kinase (NIK), which itself is a central regulator for NFκB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ , and each appear to make essential contributions to IκB phosphorylation. Alternative Name :
I kappa B alpha; I kappa B alpha; I(Kappa)B(alpha); I(Kappa)B(alpha); I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA; IKBA; IKBalpha; MAD 3; MAD 3; MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer binding protein MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBI; NFKBIA; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B c Swiss-Prot :
P25963 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IkB-α (Y42). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using AP0643 IkB-α (Y42) pAb.
Blocking peptide available as AP0643PP