Bim (A2) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Bim (A2) Peptide Applications :
Blocking Background :
Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS or BimL, implying a unique role for BimEL in cell survival signaling. Alternative Name :
Bcl2-interacting mediator of cell death; BIM; BIM Swiss-Prot :
O43521 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Bim (A2). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1035 Bim (A2) pAb.
Bim (A2) Peptide Applications :
Blocking Background :
Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS or BimL, implying a unique role for BimEL in cell survival signaling. Alternative Name :
Bcl2-interacting mediator of cell death; BIM; BIM Swiss-Prot :
O43521 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Bim (A2). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1035 Bim (A2) pAb.
Blocking peptide available as BS1035PP