TFDP1 (V393) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TFDP1 (V393) Peptide Applications :
Blocking Background :
The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2. Alternative Name :
DP - 1 Transcription Factor; E2F dimerization partner 1; DRTF1-polypeptide 1; DRTF1; DP1; 7027; TFDP1; 189902; Q14186; DP1; DRTF1; Dp-1; Swiss-Prot :
Q14186 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TFDP1 (V393). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1093 TFDP1 (V393) pAb.
TFDP1 (V393) Peptide Applications :
Blocking Background :
The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2. Alternative Name :
DP - 1 Transcription Factor; E2F dimerization partner 1; DRTF1-polypeptide 1; DRTF1; DP1; 7027; TFDP1; 189902; Q14186; DP1; DRTF1; Dp-1; Swiss-Prot :
Q14186 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TFDP1 (V393). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1093 TFDP1 (V393) pAb.
Blocking peptide available as BS1093PP