FANCD2 (P216) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
FANCD2 (P216) Peptide Applications :
Blocking Background :
The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms. Alternative Name :
Fanconi anemia group D2 protein; FACD2; FANCD2; FACD Swiss-Prot :
Q9BXW9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide FANCD2 (P216). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1120 FANCD2 (P216) pAb.
FANCD2 (P216) Peptide Applications :
Blocking Background :
The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC(Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451 amino acid nuclear protein that exists as two protein isoforms. Alternative Name :
Fanconi anemia group D2 protein; FACD2; FANCD2; FACD Swiss-Prot :
Q9BXW9 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide FANCD2 (P216). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1120 FANCD2 (P216) pAb.
Blocking peptide available as BS1120PP