Neuregulin-1/SMDF (Y4) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Neuregulin-1/SMDF (Y4) Peptide Applications :
Blocking Background :
The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Alternative Name :
NRG1; ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; NDF; PRO-NRG1; SMDF Swiss-Prot :
Q15491 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Neuregulin-1/SMDF (Y4). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1173 Neuregulin-1/SMDF (Y4) pAb.
Neuregulin-1/SMDF (Y4) Peptide Applications :
Blocking Background :
The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Alternative Name :
NRG1; ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; NDF; PRO-NRG1; SMDF Swiss-Prot :
Q15491 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Neuregulin-1/SMDF (Y4). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1173 Neuregulin-1/SMDF (Y4) pAb.
Blocking peptide available as BS1173PP