MMP-1 (H440) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
MMP-1 (H440) Peptide Applications :
Blocking Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression Alternative Name :
MAP2K6; EC 2.7.12.2; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3 Swiss-Prot :
P03956 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MMP-1 (H440). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1229 MMP-1 (H440) pAb.
MMP-1 (H440) Peptide Applications :
Blocking Background :
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression Alternative Name :
MAP2K6; EC 2.7.12.2; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3 Swiss-Prot :
P03956 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide MMP-1 (H440). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1229 MMP-1 (H440) pAb.
Blocking peptide available as BS1229PP