Nibrin (T337) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Nibrin (T337) Peptide Applications :
Blocking Background :
DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Dmc1 and nibrin. Dmc1 is specifically involved in meiotic recombination. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Alternative Name :
Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1; NBN; NBS; NBS1; P95 Swiss-Prot :
O60934 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Nibrin (T337). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1282 Nibrin (T337) pAb.
Nibrin (T337) Peptide Applications :
Blocking Background :
DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the double-strand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Dmc1 and nibrin. Dmc1 is specifically involved in meiotic recombination. Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Alternative Name :
Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1; NBN; NBS; NBS1; P95 Swiss-Prot :
O60934 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Nibrin (T337). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1282 Nibrin (T337) pAb.
Blocking peptide available as BS1282PP