PDK1 (K235) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PDK1 (K235) Peptide Applications :
Blocking Background :
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research. Alternative Name :
PDK1; PDPK1; hPDK1; 3-phosphoinositide-dependent protein kinase 1 Swiss-Prot :
O15530 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PDK1 (K235). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1291 PDK1 (K235) pAb.
PDK1 (K235) Peptide Applications :
Blocking Background :
PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of hosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research. Alternative Name :
PDK1; PDPK1; hPDK1; 3-phosphoinositide-dependent protein kinase 1 Swiss-Prot :
O15530 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PDK1 (K235). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1291 PDK1 (K235) pAb.
Blocking peptide available as BS1291PP