PSEN1/ PS-1 (S28) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PSEN1/ PS-1 (S28) Peptide Applications :
Blocking Background :
A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer’s disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer’s disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library. Alternative Name :
PSEN1; AD3; FAD; PS-1; PS1; S182; Presenilin 1 Swiss-Prot :
P49768 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PSEN1/ PS-1 (S28). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1298 PSEN1/ PS-1 (S28) pAb.
PSEN1/ PS-1 (S28) Peptide Applications :
Blocking Background :
A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer’s disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer’s disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library. Alternative Name :
PSEN1; AD3; FAD; PS-1; PS1; S182; Presenilin 1 Swiss-Prot :
P49768 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PSEN1/ PS-1 (S28). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1298 PSEN1/ PS-1 (S28) pAb.
Blocking peptide available as BS1298PP