TGF β3 (G292) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
TGF β3 (G292) Peptide Applications :
Blocking Background :
Transforming growth factor betas (TGFβs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFα. It is now realized that TGFβs mediate many cell-cell interactions that occur during embryonic develop ment. Three TGFβs have been identified in mam mals. TGFβ1, TGFβ2 and TGFβ3 are each syn thesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the mol ecules. Biologically active TGFβ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFβ3 protein has approx imately 80% identity to the mature region of both TGFβ1 and TGFβ2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. Alternative Name :
Transforming growth factor beta-3; TGF-beta-3; Latency-associated peptide; LAP; TGFB3; TGFβ3; TGF β3 Swiss-Prot :
P10600 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TGF β3 (G292). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1363 TGF β3 (G292) pAb.
TGF β3 (G292) Peptide Applications :
Blocking Background :
Transforming growth factor betas (TGFβs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFα. It is now realized that TGFβs mediate many cell-cell interactions that occur during embryonic develop ment. Three TGFβs have been identified in mam mals. TGFβ1, TGFβ2 and TGFβ3 are each syn thesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the mol ecules. Biologically active TGFβ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFβ3 protein has approx imately 80% identity to the mature region of both TGFβ1 and TGFβ2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. Alternative Name :
Transforming growth factor beta-3; TGF-beta-3; Latency-associated peptide; LAP; TGFB3; TGFβ3; TGF β3 Swiss-Prot :
P10600 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TGF β3 (G292). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1363 TGF β3 (G292) pAb.
Blocking peptide available as BS1363PP