4E-BP1 (N63) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
4E-BP1 (N63) Peptide Applications :
Blocking Background :
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E. Alternative Name :
EIF4EBP1; 4E-BP1; 4EBP1; PHAS-I Swiss-Prot :
Q13541 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 4E-BP1 (N63). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1376 4E-BP1 (N63) pAb.
4E-BP1 (N63) Peptide Applications :
Blocking Background :
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E. Alternative Name :
EIF4EBP1; 4E-BP1; 4EBP1; PHAS-I Swiss-Prot :
Q13541 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide 4E-BP1 (N63). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1376 4E-BP1 (N63) pAb.
Blocking peptide available as BS1376PP