GSK3α/β (G273) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
GSK3α/β (G273) Peptide Applications :
Blocking Background :
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. Alternative Name :
Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B Swiss-Prot :
P49840/P49841 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GSK3α/β (G273). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1412 GSK3α/β (G273) pAb.
GSK3α/β (G273) Peptide Applications :
Blocking Background :
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. Alternative Name :
Glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK3A; Glycogen synthase kinase-3 beta; GSK-3 beta; GSK3B Swiss-Prot :
P49840/P49841 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide GSK3α/β (G273). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1412 GSK3α/β (G273) pAb.
Blocking peptide available as BS1412PP