IRAK1 (T381) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
IRAK1 (T381) Peptide Applications :
Blocking Background :
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB. Alternative Name :
Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK1; IRAK Swiss-Prot :
P51617 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IRAK1 (T381). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1541 IRAK1 (T381) pAb.
IRAK1 (T381) Peptide Applications :
Blocking Background :
Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Two distinct receptors designated IL-1RI and IL-1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL-1RI to be the functional IL-1 receptor. Binding of IL-1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL-1-dependent kinase termed IRAK (for IL-1 receptor-associated kinase) co-immunoprecipitates with activated IL-1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB. Alternative Name :
Interleukin-1 receptor-associated kinase 1; IRAK-1; IRAK1; IRAK Swiss-Prot :
P51617 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IRAK1 (T381). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1541 IRAK1 (T381) pAb.
Blocking peptide available as BS1541PP