PTP1B (Y46) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
PTP1B (Y46) Peptide Applications :
Blocking Background :
The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is areversible process, involving both enzymes that phosphorylate proteins ontyrosine residues as well as a rapidly expanding family of protein tyrosinephosphatases. These latter enzymes bear little resemblance to either theprotein serine and protein threonine phosphatases or to the acid and alkalinephosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein of approximately 40 kDa molecular weight. On the basis of sequence analysis, PTP1B expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, ahomolog of the neural adhesion molecule (NCAM). PTPase 1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme. Alternative Name :
PTPN1; EC 3.1.3.48; PTP-1B; PTP1B Swiss-Prot :
P18031 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PTP1B (Y46). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1589 PTP1B (Y46) pAb.
PTP1B (Y46) Peptide Applications :
Blocking Background :
The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is areversible process, involving both enzymes that phosphorylate proteins ontyrosine residues as well as a rapidly expanding family of protein tyrosinephosphatases. These latter enzymes bear little resemblance to either theprotein serine and protein threonine phosphatases or to the acid and alkalinephosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein of approximately 40 kDa molecular weight. On the basis of sequence analysis, PTP1B expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, ahomolog of the neural adhesion molecule (NCAM). PTPase 1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme. Alternative Name :
PTPN1; EC 3.1.3.48; PTP-1B; PTP1B Swiss-Prot :
P18031 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide PTP1B (Y46). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1589 PTP1B (Y46) pAb.
Blocking peptide available as BS1589PP