Product Name :
TK (P7) Peptide Applications :
Blocking Background :
Thymidine kinase 2 (TK2) salvages mitochondrial (mt) pyrimidine deoxynucleosides for mtDNA precursor synthesis. TK2 phosphorylates these nucleosides to their corresponding nucleoside monophosphates using a nucleotide triphosphate as a donor. Deficiency of mitochondrial TK2 manifests as severe skeletal myopathy during infancy, due to depletion of mtDNA. Mutant enzyme possesses similar K(m) values to wild type, however, the V(max) is markedly decreased, leading to the decreased enzyme efficiency, which causes the disease. Alternative Name :
TK1; EC 2.7.1.21; TK2 Swiss-Prot :
P04183 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide TK (P7). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1601 TK (P7) pAb.

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Blocking peptide available as BS1601PP