Tuberin (L1456) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Tuberin (L1456) Peptide Applications :
Blocking Background :
Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a 180 kDa protein, 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. Alternative Name :
Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4 Swiss-Prot :
P49815 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Tuberin (L1456). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1605 Tuberin (L1456) pAb.
Tuberin (L1456) Peptide Applications :
Blocking Background :
Tuberous sclerosis (TSC) is a human genetic disorder characterized by mental retardation and the widespread development of benign and infrequently malignant tumors in a variety of tissues. Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a 180 kDa protein, 1784 amino acids in length, called tuberin. Tuberin exhibits a region of limited homology to the catalytic domain of Rap1 GAP. Subcellular fractionation studies have shown tuberin to be predominantly localized in membrane fractions. Tuberin is capable of stimulating the intrinsic GTPase activity of Rap 1A, but not Rap 2, H-Ras, Rac or Rho. TSC2 maps to human chromosome 16 and is associated with several intragenic mutations in affected patients. The mouse homolog of the tuberin gene maps to chromosome 17. Alternative Name :
Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4 Swiss-Prot :
P49815 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Tuberin (L1456). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1605 Tuberin (L1456) pAb.
Blocking peptide available as BS1605PP