Fos B (S23) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
Fos B (S23) Peptide Applications :
Blocking Background :
Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes. Alternative Name :
FOSB; DKFZP686C0818; G0S3; GOS3; GOSB; MGC42291 Swiss-Prot :
P53539 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Fos B (S23). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1645 Fos B (S23) pAb.
Fos B (S23) Peptide Applications :
Blocking Background :
Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes. Alternative Name :
FOSB; DKFZP686C0818; G0S3; GOS3; GOSB; MGC42291 Swiss-Prot :
P53539 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide Fos B (S23). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1645 Fos B (S23) pAb.
Blocking peptide available as BS1645PP