HAT1 (S361) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
HAT1 (S361) Peptide Applications :
Blocking Background :
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Alternative Name :
HAT1; EC 2.3.1.48; HAT1; 8520; HAT1; 603053; O14929; Swiss-Prot :
O14929 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HAT1 (S361). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1650 HAT1 (S361) pAb.
HAT1 (S361) Peptide Applications :
Blocking Background :
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Alternative Name :
HAT1; EC 2.3.1.48; HAT1; 8520; HAT1; 603053; O14929; Swiss-Prot :
O14929 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide HAT1 (S361). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1650 HAT1 (S361) pAb.
Blocking peptide available as BS1650PP