IRP-1 (R134) Peptide 
Datasheet
COA
MSDS
SHIP
Product Name :
IRP-1 (R134) Peptide Applications :
Blocking Background :
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide. Alternative Name :
ACO1; ACONITASE; EC 4.2.1.3; IREB1; IREBP; IRP1 Swiss-Prot :
P21399 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IRP-1 (R134). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1670 IRP-1 (R134) pAb.
IRP-1 (R134) Peptide Applications :
Blocking Background :
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide. Alternative Name :
ACO1; ACONITASE; EC 4.2.1.3; IREB1; IREBP; IRP1 Swiss-Prot :
P21399 Product :
1 mg/ml in DI water. Purification&Purity :
Synthetic peptide IRP-1 (R134). (Note: the amino acid sequence is proprietary). The purity is > 98%. Storage&Stability :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity :
This peptide can be used with studies using BS1670 IRP-1 (R134) pAb.
Blocking peptide available as BS1670PP